Clomipramine HCl
Clomipramine HCl structure
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Common Name | Clomipramine HCl | ||
|---|---|---|---|---|
| CAS Number | 17321-77-6 | Molecular Weight | 351.313 | |
| Density | N/A | Boiling Point | 434.2ºC at 760 mmHg | |
| Molecular Formula | C19H24Cl2N2 | Melting Point | 189-190°C | |
| MSDS | Chinese USA | Flash Point | 216.4ºC | |
| Symbol |
GHS07, GHS08, GHS09 |
Signal Word | Warning | |
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Salt effects in electromembrane extraction.
J. Chromatogr. A. 1347 , 1-7, (2014) Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs ... |
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A qualitative method for prediction of amine oxidation in methanol and water.
J. Pharm. Sci. 104(4) , 1409-20, (2015) We have developed a predictive method, based on quantum chemical calculations, that qualitatively predicts N-oxidation by hydrogen peroxides in drug structures. The method uses linear correlations of two complementary approaches to estimate the activation bar... |
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Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.
Life Sci. 92(23) , 1138-44, (2013) In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between noradrenaline (NA) release in the LC and efficacy of analge... |
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Application of electro-enhanced solid phase microextraction combined with gas chromatography-mass spectrometry for the determination of tricyclic antidepressants in environmental water samples.
J. Chromatogr. A. 1350 , 15-22, (2014) A fast and efficient method for the determination of tricyclic antidepressants using electro-enhanced solid phase microextraction (SPME) coupled to gas chromatography-mass spectrometry (GC-MS) has been developed. One advantage of this approach is that the mas... |
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A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.
Sci. Transl. Med. 7 , 290ra89, (2015) Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical ... |
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An improved analytical strategy combining microextraction by packed sorbent combined with ultra high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine.
J. Chromatogr. A. 1408 , 30-40, (2015) A powerful and sensitive method, by microextraction packed sorbent (MEPS), and ultra-high performance liquid chromatography (UHPLC) with a photodiode array (PDA) detection, is described for the determination of fluoxetine, clomipramine and their active metabo... |
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Notch signaling-related therapeutic strategies with novel drugs in neuroblastoma spheroids.
J. Pediatr. Hematol. Oncol. 36(1) , 37-44, (2014) Neuroblastoma is a severe pediatric tumor characterized by poor prognosis. Identification of novel molecular targets and diversion of investigations on new drug trials is mandatory for cancer therapy. In this study, vinorelbine tartrate, lithium chloride, clo... |
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The immediate and the delayed effects of buspirone on zebrafish (Danio rerio) in an open field test: a 3-D approach.
Behav. Brain Res. 234(2) , 365-74, (2012) Behavioral changes in zebrafish induced by acute administration of buspirone have been interpreted to be the result of reduced anxiety. The purpose of the current study was to determine whether the effects of short-term and mid-term habituation to an open fie... |
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Intravenous lipid emulsion-augmented plasma exchange in a rabbit model of clomipramine toxicity; survival, but no sink.
Clin. Toxicol. (Phila.) 52(1) , 13-9, (2014) Intravenous lipid emulsion (ILE) has been shown to ameliorate toxicity from lipophilic xenobiotics, attributed in part through sequestration to circulating lipid droplets (sink). We postulated additional benefit with plasma exchange therapy undertaken subsequ... |
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Phospholipase D-mTOR signaling is compromised in a rat model of depression.
J. Psychiatr. Res. 47(5) , 579-85, (2013) Depression is associated with structural and neurochemical changes in limbic structures, including the hippocampus, that control emotion and mood. Structural abnormalities such as decrease in hippocampal cell proliferation, neurogenesis and hippocampal volume... |