Teniposide
Teniposide structure
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Common Name | Teniposide | ||
|---|---|---|---|---|
| CAS Number | 29767-20-2 | Molecular Weight | 656.654 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 864.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C32H32O13S | Melting Point | 274 - 277ºC | |
| MSDS | Chinese USA | Flash Point | 476.5±34.3 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation.
J. Pediatr. Hematol. Oncol. 36(6) , e335-40, (2014) There are no standardized diagnostic or treatment guidelines for patients with advanced unilateral retinoblastoma.Patients with advanced unilateral retinoblastoma were prospectively treated after enucleation using a risk-based protocol. Patients were assigned... |
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Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells.
Oncol. Rep. 28(3) , 969-76, (2012) Medulloblastoma (MB) is one of the most common malignant brain tumors of childhood and is associated with a poor prognosis. Gap-junctional intercellular communication (GJIC) is an important mode for cell-to-cell communication. Dysfunctional GJIC is exhibited ... |
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Dose intensification of methotrexate and cytarabine during intensified continuation chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: POG 9406: a report from the Children's Oncology Group.
J. Pediatr. Hematol. Oncol. 36(5) , 353-61, (2014) To determine the efficacy and toxicity of higher dose versus standard dose intravenous methotrexate (MTX) and pulses of high-dose cytosine arabinoside with asparaginase versus standard dose cytosine arabinoside and teniposide during intensified continuation t... |
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Knockdown of apoptosis repressor with caspase recruitment domain (ARC) increases the sensitivity of human glioma cell line U251MG to VM-26.
Int. J. Clin. Exp. Pathol. 5(6) , 555-61, (2012) Previous studies have demonstrated that apoptosis repressor with caspase recruitment domain (ARC) is up-regulated in many forms of malignant tumors and low levels of ARC protein were expressed in normal human brain tissue. Little is known expression of ARC in... |
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A cremophor-free self-microemulsified delivery system for intravenous injection of teniposide: evaluation in vitro and in vivo.
AAPS PharmSciTech 13(3) , 846-52, (2012) In order to tackle the problems on low water solubility of teniposide, involvement of toxic surfactant in its injection, and the poor stability during infusion, a Cremophor-free teniposide self-microemulsified drug delivery system (TEN-SMEDDS) was prepared fo... |
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Study on clinical therapeutic effect including symptoms, eye preservation rate, and follow-up of 684 children with retinoblastoma.
Eur. J. Ophthalmol. 23(4) , 532-8, (2013) Retinoblastoma is the most common type of primary malignant intraocular tumor in children. The purpose of this study is to summarize the clinical experience of diagnosis and treatment for retinoblastoma, aiming to provide appropriate knowledge for surveillanc... |
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Chemotherapy for brain metastases from small cell lung cancer.
Cochrane Database Syst. Rev. 6 , CD007464, (2012) Small cell lung cancer (SCLC) accounts for approximately 20% of all cases of lung cancer. It tends to disseminate early in the course of its natural history and to grow quickly. Approximately 10% to 18% of patients present with brain metastases (BM) at the ti... |
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A phase II study with teniposide (VM26) in patients with progressed or relapsed small cell lung cancer (SCLC).
J. Chemother. 1(1) , 64-7, (1989) Sixteen patients with advanced small cell lung cancer who relapsed or progressed under first-line therapy, were treated with second-line chemotherapy consisting of: teniposide, 60 mg/m2, i.v. days 1-5, every 3 weeks until further progression. The response rat... |
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Higher LRRFIP1 expression in glioblastoma multiforme is associated with better response to teniposide, a type II topoisomerase inhibitor.
Biochem. Biophys. Res. Commun. 446(4) , 1261-7, (2014) Previous studies from this laboratory indicated that microRNA-21 (miR-21) contributes to chemoresistance of glioblastoma multiforme (GBM) cells to teniposide, a type II topoisomerase inhibitor. We also showed that LRRFIP1 is a target of miR-21. In this study,... |
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Comparison on therapeutic effects of RFT and RCTVP regimen in the treatment of patients with indolent B-cell lymphoma in China.
Med. Oncol. 29(4) , 2372-8, (2012) To compare the efficacy and safety of RFT (retuximab, fludarabine, pirarubicin) with RCTVP (retuximab, cyclophophamide, pirarubicin, vindesine and prednisone) in 248 indolent B-cell non-Hodgkin's lymphoma (NHL) patients. Two hundred and forty-eight patients w... |