Venlafaxine hydrochloride
Venlafaxine hydrochloride structure
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Common Name | Venlafaxine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 99300-78-4 | Molecular Weight | 313.863 | |
| Density | 1.394 g/cm3 | Boiling Point | 397.6ºC at 760 mmHg | |
| Molecular Formula | C17H28ClNO2 | Melting Point | 207-209ºC | |
| MSDS | USA | Flash Point | 194.2ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Environmental friendly method for urban wastewater monitoring of micropollutants defined in the Directive 2013/39/EU and Decision 2015/495/EU.
J. Chromatogr. A. 1418 , 140-9, (2015) The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directiv... |
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The antidepressant venlafaxine disrupts brain monoamine levels and neuroendocrine responses to stress in rainbow trout.
Environ. Sci. Technol. 48(22) , 13434-42, (2014) Venlafaxine, a serotonin-norepinephrine reuptake inhibitor, is a widely prescribed antidepressant drug routinely detected in the aquatic environment. However, little is known about its impact on the physiology of nontarget organisms. We tested the hypothesis ... |
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Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry.
J. Chromatogr. A. 1363 , 226-235, (2014) The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method for the quantification of seven pairs of enantiomers of pha... |
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Different serum BDNF levels in depression: results from BDNF studies in FYR Macedonia and Bulgaria.
Psychiatr. Danub. 25(2) , 123-7, (2013) A growing body of evidence shows that brain-derived neurotrophic factor (BDNF) plays a role in depressive disorder. Serum BDNF levels are lower in depressed patients and they increase after a long course of antidepressant treatment. Our study aims to test the... |
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Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: leptin resistance mediated by antihistaminergic activity?
J. Clin. Psychopharmacol. 33(1) , 99-103, (2013) Treatment with several psychopharmacological agents has been associated with increased leptin plasma concentrations. We measured leptin plasma concentrations in 76 adult depressed patients after a 6-day washout phase and again after 35 days of treatment with ... |
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Low-dose estradiol and the serotonin-norepinephrine reuptake inhibitor venlafaxine for vasomotor symptoms: a randomized clinical trial.
JAMA Intern. Med. 174(7) , 1058-66, (2014) Estrogen therapy is the gold standard treatment for hot flashes and night sweats, but some women are unable or unwilling to use it because of associated risks. The serotonin-norepinephrine reuptake inhibitor venlafaxine hydrochloride is used widely as a nonho... |
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Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice.
Behav. Pharmacol. 26 , 681-90, (2015) We have recently found that isolation-reared mice show hyperactivity during an encounter with an intruder. However, it is not known whether encounter-induced hyperactivity may model some aspects of psychiatric disorders. The present study examined the pharmac... |
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The influence of caffeine on the activity of moclobemide, venlafaxine, bupropion and milnacipran in the forced swim test in mice.
Life Sci. 136 , 13-8, (2015) Worrying data indicate that excessive caffeine intake applies to patients suffering from mental disorders, including depression. It is thus possible to demonstrate the usefulness of caffeine and its derivatives in the treatment of depression. The main goal of... |
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Case report: quetiapine and refractory hypotension during general anesthesia in the operating room.
Anesth. Analg. 117(3) , 641-3, (2013) Quetiapine is an atypical antipsychotic with known α-adrenergic antagonism. We present a case of refractory hypotension that occurred after induction of general anesthesia in a patient being treated with quetiapine. This patient was not currently taking antih... |
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Novel CYP2D6 and CYP2C19 variants identified in a patient with adverse reactions towards venlafaxine monotherapy and dual therapy with nortriptyline and fluoxetine.
Pharmacogenet. Genomics 23(9) , 494-7, (2013) We present a case report of novel variants of CYP2D6 and CYP2C19 identified in a patient who experienced adverse effects during antidepressant therapy. CYP2D6 DNA sequencing revealed that the patient was most likely an intermediate metabolizer, owing to the p... |