Meloxicam
Meloxicam structure
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Common Name | Meloxicam | ||
|---|---|---|---|---|
| CAS Number | 71125-38-7 | Molecular Weight | 351.401 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 581.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C14H13N3O4S2 | Melting Point | 255ºC | |
| MSDS | N/A | Flash Point | 305.4±32.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Quantitation of meloxicam in the plasma of koalas (Phascolarctos cinereus) by improved high performance liquid chromatography.
J. Vet. Sci. 14(1) , 7-14, (2013) An improved method to determine meloxicam (MEL) concentrations in koala plasma using reversed phase high performance liquid chromatography equipped with a photo diode array detector was developed and validated. A plasma sample clean-up step was carried out wi... |
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Effects of meloxicam and phenylbutazone on renal responses to furosemide, dobutamine, and exercise in horses.
Am. J. Vet. Res. 75(7) , 668-79, (2014) To compare the effects of 2 NSAIDs (phenylbutazone and meloxicam) on renal function in horses.9 Thoroughbred or Standardbred mares (mean ± SD age, 5.22 ± 1.09 years [range, 2 to 12 years]; mean body weight, 470 ± 25 kg [range, 442 to 510 kg]).A randomized bli... |
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Meloxicam-loaded nanocapsules have antinociceptive and antiedematogenic effects in acute models of nociception
Life Sci. 115(1-2) , 36-43, (2014) Aims The development of new treatments for inflammation and pain continues to be of high interest, since long-acting effect is critical for patients. The present study investigated whether the polymeric nanocapsules, a drug delivery system, have pharmacologic... |
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Aspirin but not meloxicam attenuates early atherosclerosis in apolipoprotein E knockout mice.
Isr. Med. Assoc. J. 16(4) , 233-8, (2014) Atherosclerosis is a complex vascular inflammatory disease. In the last decade it was suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) and in particular inhibition of cyclooxygenase (COX)-2 are associated with an increase in cardiovascular morbidi... |
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Pin1 is required for ultraviolet A-stimulated cyclooxygenase-2 induction in mouse epidermal cells
Cancer Lett. 335(1) , 31-40, (2013) Highlights ► Pin1 and COX-2 are frequently overexpressed in most cancer cell types and plays an important role in oncogenesis. ► We studied whether exposure of epidermal cells to UVA affects COX-2 expression and the possible involvement of Pin1 activation. ► ... |
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Effects of meloxicam and phenylbutazone on equine gastric mucosal permeability.
J. Vet. Intern. Med. 26(6) , 1494-9, (2012) Newer NSAIDs that more selectively target the induced isoform of the cyclooxygenase enzyme (COX2) activity might reduce adverse effects while preserving therapeutic benefits of these drugs.To compare the effect of oral administration of multiple dose rates of... |
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Toxic influence.
Nature 514(7523) , 404, (2014)
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Dexamethasone, but not meloxicam, suppresses proliferation of bovine CD25+ CD4+ and CD25- CD4+ T cells.
Pol. J. Vet. Sci. 16(2) , 219-22, (2013) Recently, we found that dexamethasone caused a depletion of CD25- CD4+ T cells, but it increased the number of CD25highCD4+ and CD25lowCD4+ T cells. We also determined meloxicam-induced increase in the number of CD25highCD4+ T cells. In view of this, and taki... |
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Nanoemulsion based gel for transdermal delivery of meloxicam: physico-chemical, mechanistic investigation.
Life Sci. 92(6-7) , 383-92, (2013) The aim of the present investigation was to develop a nanoemulsion (NE) gel formulation for the transdermal delivery of meloxicam (MLX) in order to ensure maximum controlled and sustained drug release capacity.The MLX containing NE gel was prepared and charac... |
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Meloxicam.
Drugs 51(3) , 424-30; discussion 431-32, (1996) Meloxicam is a new nonsteroidal anti-inflammatory drug (NSAID) developed for the treatment of rheumatoid arthritis and osteoarthritis. It has greater in vitro and in vivo inhibitory action against the inducible isoform of cyclo-oxygenase (COX-2), which is imp... |