β-Estradiol 3-(β-D-glucuronide) sodium salt
β-Estradiol 3-(β-D-glucuronide) sodium salt structure
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Common Name | β-Estradiol 3-(β-D-glucuronide) sodium salt | ||
|---|---|---|---|---|
| CAS Number | 14982-12-8 | Molecular Weight | 470.488 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H31NaO8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Oestradiol 17 beta-glucuronide increases tight-junctional permeability in rat liver.
Biochem. J. 261(1) , 297-300, (1989) By using rat liver perfusion under one-pass conditions with a single pulse of horseradish peroxidase (HRP), the biliary output of HRP was used as an indicator of paracellular permeability change caused by the cholestatic compound oestradiol 17 beta-glucuronid... |
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Coregulation of C3-hydroxyl versus C17-hydroxyl glucuronidation of beta-estradiol in pregnancy and after treatment with phenobarbital or ethinyl-estradiol.
J. Pharmacol. Exp. Ther. 246(1) , 54-9, (1988) The glucuronidation of [3H]estradiol-17 beta at the C3 vs. the C17 hydroxyl groups was determined in female Sprague-Dawley rat liver microsomes. A high-performance liquid chromatography method was developed to resolve the glucuronide conjugates which were the... |
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Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity.
Xenobiotica 40(10) , 663-9, (2010) Commonly used herbal supplements were screened for their potential to inhibit UGT1A1 activity using human liver microsomes. Extracts screened included ginseng, echinacea, black cohosh, milk thistle, garlic, valerian, saw palmetto, and green tea epigallocatech... |
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In vivochronic exposure to heroin or naltrexone selectively inhibits liver microsome formation of estradiol-3-glucuronide in the rat
Biochem. Pharmacol. 76(5) , 672-9, (2008) We have previously found that repeated exposure to heroin reduces liver synthesis of morphine-3-glucuronide (M3G) and increases the production of morphine-6-glucuronide (M6G), which normally is not formed in the rat. By contrast repeated exposure to naltrexon... |
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Drug-induced cholestasis in the perfused rat liver and its reversal by tauroursodeoxycholate: an ultrastructural study.
Proc. Soc. Exp. Biol. Med. 199(1) , 54-8, (1992) Chlorpromazine at a concentration of 250 microM and estradiol-17 beta-D-glucuronide at 17.5 microM on infusion led to a sharp reduction in bile flow by the in vitro perfused rat liver. This was accompanied by fragmentation and a loss of canalicular microvilli... |
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Biliary secretion of glutathione in estradiol 17beta-D-glucuronide-induced cholestasis.
J. Pharmacol. Exp. Ther. 307(1) , 306-13, (2003) Estradiol-17beta-D-glucuronide (E2-17G) induces an acute but reversible inhibition of bile flow after its intravenous administration to rats, due in part to the endocytic retrieval of the canalicular multidrug resistance-associated transporter protein 2 and t... |
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Characterization of [3H]estradiol-17 beta-(beta-D-glucuronide) binding sites in basolateral and canalicular liver plasma membranes.
Biochem. Pharmacol. 40(6) , 1219-25, (1990) The specific binding of [3H]estradiol-17 beta-(beta-D-glucuronide) ([3H]E217G) was examined in isolated basolateral (bLPM) and canalicular (cLPM) liver plasma membranes. Two distinct binding sites were identified in each membrane fraction by competition and s... |
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A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles.
Anal. Biochem. 310(1) , 61-6, (2002) This study investigated a high-throughput assay to measure multidrug resistance-associated protein (MRP1)-mediated uptake into membrane vesicles. Typically, a rapid filtration technique using a 12-filter vacuum manifold is used. We report here the development... |
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Evaluation of urinary oestrogen assays after the menopause and their potential for screening.
Clin. Chim. Acta 176(1) , 71-81, (1988) Urinary oestrone-3-glucuronide, oestradiol-3-glucuronide, oestrone and oestradiol were measured by radioimmunoassay methods adapted for the very low levels found in postmenopausal women. Oestrogen concentrations related to creatinine in morning urine samples ... |
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Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2).
Pharmacogenet. Genomics 21(8) , 506-15, (2011) Multidrug resistance-associated protein 2 (MRP2; ABCC2) mediates the biliary excretion of glutathione, glucuronide, and sulfate conjugates of endobiotics and xenobiotics. Single nucleotide polymorphisms (SNPs) of MRP2 contribute to interindividual variability... |