KG-501
KG-501 structure
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Common Name | KG-501 | ||
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| CAS Number | 18228-17-6 | Molecular Weight | 377.71600 | |
| Density | 1.567g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C17H13ClNO5P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Fungal recognition enhances mannose receptor shedding through dectin-1 engagement.
J. Biol. Chem. 286(10) , 7822-9, (2011) The mannose receptor (MR) is an endocytic type I membrane molecule with a broad ligand specificity that is involved in both hemostasis and pathogen recognition. Membrane-anchored MR is cleaved by a metalloproteinase into functional soluble MR (sMR) composed o... |
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Development of a pluripotent stem cell derived neuronal model to identify chemically induced pathway perturbations in relation to neurotoxicity: effects of CREB pathway inhibition.
Toxicol. Appl. Pharmacol. 280(2) , 378-88, (2014) According to the advocated paradigm shift in toxicology, acquisition of knowledge on the mechanisms underlying the toxicity of chemicals, such as perturbations of biological pathways, is of primary interest. Pluripotent stem cells (PSCs), such as human embryo... |
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Transcription factor cyclic adenosine monophosphate responsive element binding protein negatively regulates tumor necrosis factor alpha-induced protein 1 expression.
Mol. Med. Report. 12 , 7763-9, (2015) Tumor necrosis factor alpha (TNFα)-induced protein 1 (TNFAIP1) was originally identified as a protein involved in DNA replication, DNA damage repair, apoptosis and the progression of certain diseases, such as Alzheimer's disease. In the present study, forskol... |
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Identification of small-molecule antagonists that inhibit an activator: coactivator interaction.
Proc. Natl. Acad. Sci. U. S. A. 101 , 17622-17627, (2004) Phosphorylation of the cAMP response element binding protein (CREB) at Ser-133 in response to hormonal stimuli triggers cellular gene expression via the recruitment of the histone acetylase coactivator paralogs CREB binding protein (CBP) and p300 to the promo... |
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Nuclear TRAF3 is a negative regulator of CREB in B cells.
Proc. Natl. Acad. Sci. U. S. A. 113 , 1032-7, (2016) The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signaling through B-lymphocyte receptors, including CD40, BAFF receptor, and Toll-like receptors, and also plays a critical role inhibiting B-cell homoeostatic survival. Consistent with th... |
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Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells.
PLoS ONE 6 , e28280, (2011) 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange. In this research, we report the first investigation of the neurotrophic effects and... |
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Luteolin induces microRNA-132 expression and modulates neurite outgrowth in PC12 cells.
PLoS ONE 7 , e43304, (2012) Luteolin (3',4',5,7-tetrahydroxyflavone), a food-derived flavonoid, has been reported to exert neurotrophic properties that are associated with its capacity to promote neuronal survival and neurite outgrowth. In this study, we report for the first time that l... |
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Phosphates of the naphthol AS series in the quantitative determination of alkaline and acid phosphatase activities in situ studied in polyacrylamide membrane model systems and by cytospectrophotometry Lojda, Z., et al.
Histochem. Cell Biol. 11 , 13-32, (1967)
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