(2R,3S,4R,5R)-2-deuterio-2,3,4,5,6-pentahydroxyhexanal

(2R,3S,4R,5R)-2-deuterio-2,3,4,5,6-pentahydroxyhexanal Structure
(2R,3S,4R,5R)-2-deuterio-2,3,4,5,6-pentahydroxyhexanal structure
Common Name (2R,3S,4R,5R)-2-deuterio-2,3,4,5,6-pentahydroxyhexanal
CAS Number 30737-83-8 Molecular Weight 181.16200
Density N/A Boiling Point N/A
Molecular Formula C6H11DO6 Melting Point 150-152ºC(lit.)
MSDS USA Flash Point N/A

Quantitative epistasis analysis and pathway inference from genetic interaction data.

PLoS Comput. Biol. 7(5) , e1002048, (2011)

Inferring regulatory and metabolic network models from quantitative genetic interaction data remains a major challenge in systems biology. Here, we present a novel quantitative model for interpreting epistasis within pathways responding to an external signal....

C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists.

Mol. Cell. Biol. 29(17) , 4714-28, (2009)

White adipose tissue (WAT) stores energy in the form of triglycerides, whereas brown tissue (BAT) expends energy, primarily by oxidizing lipids. WAT also secretes many cytokines and acute-phase proteins that contribute to insulin resistance in obese subjects....

Detection and localization of single LysM-peptidoglycan interactions.

J. Bacteriol. 190(21) , 7079-86, (2008)

The lysin motif (LysM) is a ubiquitous protein module that binds peptidoglycan and structurally related molecules. Here, we used single-molecule force spectroscopy (SMFS) to measure and localize individual LysM-peptidoglycan interactions on both model and cel...

A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor alpha and gamma.

Diabetes 60 , 496-506, (2011)

Peroxisome proliferator-activated receptor (PPAR)-α/γ dual agonists have been developed to alleviate metabolic disorders. However, several PPARα/γ dual agonists are accompanied with unwanted side effects, including body weight gain, edema, and tissue failure....

Micropit: A New Cell Culturing Approach for Characterization of Solitary Astrocytes and Small Networks of these Glial Cells.

Front. Neuroeng. 1 , 2, (2008)

Astrocytes play an important role in cell-cell signaling in the mammalian central nervous system. The ability of astrocytes to communicate with surrounding cells through gap-junctional coupling or signaling via the release of transmitters makes characterizati...

Genomic organization, sequence divergence, and recombination of feline immunodeficiency virus from lions in the wild.

BMC Genomics 9 , 66, (2008)

Feline immunodeficiency virus (FIV) naturally infects multiple species of cat and is related to human immunodeficiency virus in humans. FIV infection causes AIDS-like disease and mortality in the domestic cat (Felis catus) and serves as a natural model for HI...

The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus.

PLoS ONE 6(6) , e20412, (2011)

Tacrolimus (FK506) is an immunosuppressive drug that binds to the immunophilin FKBPB12. The FK506-FKBP12 complex associates with calcineurin and inhibits its phosphatase activity, resulting in inhibition of nuclear translocation of nuclear factor of activated...

Early and late pathogenic events of newborn mice encephalitis experimentally induced by itacaiunas and curionópolis bracorhabdoviruses infection.

PLoS ONE 3(3) , e1733, (2008)

In previous reports we proposed a new genus for Rhabdoviridae and described neurotropic preference and gross neuropathology in newborn albino Swiss mice after Curionopolis and Itacaiunas infections. In the present report a time-course study of experimental en...