Histrelin
Histrelin structure
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Common Name | Histrelin | ||
|---|---|---|---|---|
| CAS Number | 76712-82-8 | Molecular Weight | 1323.502 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 1800.6ºC at 760 mmHg | |
| Molecular Formula | C66H86N18O12 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 1042.8ºC | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Stability of peptide drugs in the colon.
Eur. J. Pharm. Sci. 78 , 31-6, (2015) This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser... |
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Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs.
Mol. Pharm. 12(3) , 966-73, (2015) A major barrier to successful oral delivery of peptide and protein molecules is their inherent instability in the lumen of the gastrointestinal tract. The aim of this study was to determine the stability of 17 disparate peptide drugs (insulin, calcitonin, glu... |
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Treatment and outcomes of precocious puberty: an update.
J. Clin. Endocrinol. Metab. 98(6) , 2198-207, (2013) Precocious puberty is a common problem affecting up to 29 per 100,000 girls per year. The earliest identified neuroendocrine change in early puberty thus far is increased kisspeptin secretion from the arcuate nucleus and the anteroventral paraventricular nucl... |
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Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse.
PLoS Biol. 12(9) , e1001952, (2014) Characterization of the genetic defects causing gonadotropic deficiency has made a major contribution to elucidation of the fundamental role of Kisspeptins and Neurokinin B in puberty onset and reproduction. The absence of puberty may also reveal neurodevelop... |
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Resumption of puberty in girls and boys following removal of the histrelin implant.
J. Pediatr. 164(4) , 912-916.e1, (2014) To determine time to menarche in girls and testicular volume increase in boys after removal of a histrelin implant, which causes profound hypothalamic-pituitary-gonadal axis suppression.Medical records of patients treated with a histrelin implant were reviewe... |
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R31C GNRH1 mutation and congenital hypogonadotropic hypogonadism.
PLoS ONE 8(7) , e69616, (2013) Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare reproductive disease leading to lack of puberty and infertility. Loss-of-function mutations of GNRH1 gene are a very rare cause of autosomal recessive nCHH. R31C GNRH1 is the only missense mu... |
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Characterization of 12 GnRH peptide agonists - a kinetic perspective.
Br. J. Pharmacol. 173(1) , 128-41, (2016) Drug-target residence time is an important, yet often overlooked, parameter in drug discovery. Multiple studies have proposed an increased residence time to be beneficial for improved drug efficacy and/or longer duration of action. Currently, there are many d... |
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Histrelin: in advanced prostate cancer.
Drugs 70(5) , 623-30, (2010) Histrelin is a gonadotropin-releasing hormone agonist available in a diffusion-controlled reservoir drug delivery system for subcutaneous implantation. The subcutaneous histrelin implant provided sustained suppression of serum testosterone, luteinizing hormon... |
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A review of the pharmacokinetic and pharmacological properties of a once-yearly administered histrelin acetate implant in the treatment of prostate cancer.
BJU Int. 103 Suppl 2 , 7-13, (2009)
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Effective long-term androgen suppression in men with prostate cancer using a hydrogel implant with the GnRH agonist histrelin.
Urology 58(4) , 578-82, (2001) To evaluate the effectiveness of a hydrogel implant containing the gonadotropin-releasing hormone (GnRH) agonist histrelin in suppressing testosterone production in men with prostate cancer and to determine the effective dose (one, two, or four implants).Fort... |