(1S)-2,2-Dimethylcyclopropanecarboxamide

(1S)-2,2-Dimethylcyclopropanecarboxamide Structure
(1S)-2,2-Dimethylcyclopropanecarboxamide structure
Common Name (1S)-2,2-Dimethylcyclopropanecarboxamide
CAS Number 75885-58-4 Molecular Weight 113.158
Density 1.0±0.1 g/cm3 Boiling Point 225.1±7.0 °C at 760 mmHg
Molecular Formula C6H11NO Melting Point 135-137ºC
MSDS Chinese USA Flash Point 89.9±18.2 °C
Symbol GHS07
GHS07
Signal Word Warning

Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids.

J. Med. Chem. 30 , 1074, (1987)

The title enzyme deactivates the potent carbapenem antibiotic imipenem in the kidney, producing low antibiotic levels in the urinary tract. A series of (Z)-2-(acylamino)-3-substituted-propenoic acids (3) are specific, competitive inhibitors of the enzyme capa...