Tamoxifen
Tamoxifen structure
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Common Name | Tamoxifen | ||
|---|---|---|---|---|
| CAS Number | 10540-29-1 | Molecular Weight | 371.515 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 482.3±33.0 °C at 760 mmHg | |
| Molecular Formula | C26H29NO | Melting Point | 97-98ºC | |
| MSDS | Chinese USA | Flash Point | 140.0±27.7 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27.
Biochim. Biophys. Acta 1839(11) , 1273-82, (2014) GATA4 is expressed in the proximal 85% of small intestine where it promotes a proximal intestinal ('jejunal') identity while repressing a distal intestinal ('ileal') identity, but its molecular mechanisms are unclear. Here, we tested the hypothesis that GATA4... |
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TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer.
Oncogene 34(1) , 27-38, (2015) Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF... |
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Potential therapeutic benefit of combining gefitinib and tamoxifen for treating advanced lung adenocarcinoma.
Biomed Res. Int. 2015 , 642041, (2015) Epidermal growth factor receptor (EGFR) mutations are known as oncogene driver mutations and with EGFR mutations exhibit good response to the EGFR tyrosine kinase inhibitor Gefitinib. Some studies have shown that activation of estrogen and estrogen receptor α... |
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Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.
BMC Cancer 14 , 853, (2014) The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we have further investigated the effect of the lead ... |
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Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.
Sci. Rep. 5 , 17577, (2015) Influenza virus (IFV) infection is a common cause of severe viral pneumonia associated with acute respiratory distress syndrome (ARDS), which is difficult to control with general immunosuppressive therapy including corticosteroids due to the unfavorable effec... |
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Regulatory T cells require TCR signaling for their suppressive function.
J. Immunol. 194 , 4362-70, (2015) Regulatory T cells (Tregs) are a subset of CD4(+) T cells that maintain immune tolerance in part by their ability to inhibit the proliferation of conventional CD4(+) T cells (Tconvs). The role of the TCR and the downstream signaling pathways required for this... |
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RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models.
Anticancer Drugs 26 , 948-56, (2015) Agents that inhibit estrogen production, such as aromatase inhibitors or those that directly block estrogen receptor (ER) activity, such as selective estrogen receptor modulators and selective estrogen receptor degraders, are routinely used in the treatment o... |
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Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells.
Oncogene 34 , 2823-35, (2015) Tumor-associated angiogenesis is postulated to be regulated by the balance between pro- and anti-angiogenic factors. We demonstrate here that the critical step in establishing the angiogenic capability of human tumor cells is the repression of a key secreted ... |
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Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines.
Biochem. Biophys. Res. Commun. 464 , 833-9, (2015) The sphingolipid ceramide is a pro apoptotic molecule of ceramide metabolic pathway and is hydrolyzed to proliferative metabolite, sphingosine 1 phosphate by the action of acid ceramidase. Being upregulated in the tumors of breast, acid ceramidase acts as a p... |
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Survival of effector CD8+ T cells during influenza infection is dependent on autophagy.
J. Immunol. 194 , 4277-86, (2015) The activation and expansion of effector CD8(+) T cells are essential for controlling viral infections and tumor surveillance. During an immune response, T cells encounter extrinsic and intrinsic factors, including oxidative stress, nutrient availability, and... |