Diethylcarbamazine Citrate
Diethylcarbamazine Citrate structure
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Common Name | Diethylcarbamazine Citrate | ||
|---|---|---|---|---|
| CAS Number | 1642-54-2 | Molecular Weight | 391.417 | |
| Density | N/A | Boiling Point | 297.4ºC at 760 mmHg | |
| Molecular Formula | C16H29N3O8 | Melting Point | 140 °C | |
| MSDS | Chinese USA | Flash Point | 116.6ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Liquid chromatography-mass spectrometry analysis of diethylcarbamazine in human plasma for clinical pharmacokinetic studies.
J. Pharm. Biomed. Anal. 98 , 307-10, (2014) A sensitive and selective liquid chromatographic method using mass spectrometric detection was developed for the determination of diethylcarbamazine (DEC) in human plasma. DEC and its stable isotope internal standard d3-DEC were extracted from 0.25mL of human... |
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Immunomodulatory effect of diethylcarbamazine in mice infected with Nocardia brasiliensis.
Int. Immunopharmacol. 23(1) , 113-20, (2015) We tested whether diethylcarbamazine (DEC) or ivermectin (IVM), both antiparasitic drugs with reported immunomodulatory properties, were able to affect the immune system to potentiate host defense mechanisms and protect against actinomycetoma in a mouse model... |
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Loa loa—does it deserve to be neglected?
Lancet Infect. Dis. 14(4) , 353-7, (2014) More than 10 million people in western and central Africa are estimated to be infected with Loa loa filarial nematodes. Like most other infectious diseases, L loa filariasis (loiasis) covers a wide range of symptoms. Severe complications have been reported; h... |
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In vitro and in vivo antifilarial activity evaluation of 3,6-epoxy [1,5]dioxocines: a new class of antifilarial agents.
Bioorg. Med. Chem. Lett. 22 , 1527-32, (2012) A series of 3,6-epoxy [1,5]dioxocines were synthesized and evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro. Out of these, six compounds (4a-f) possessed improv... |
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Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats.
Toxicology 300(1-2) , 92-9, (2012) The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) can induce marked nephrotoxicity in rats following a single intraperitoneal (ip) administration of 0.4mmol/kg or greater. Although NDPS induces direct renal proximal tubular toxicity, a role ... |
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Adverse reactions following mass drug administration with diethylcarbamazine in lymphatic filariasis endemic areas in the Northeast of Brazil.
Rev. Soc. Bras. Med. Trop. 45(6) , 745-50, (2012) The Global Programme to Eliminate Lymphatic Filariasis was launched with the goal of eliminating this disease via the annual mass drug administration (MDA) of a single dose of antifilarial drugs. Adverse drug reactions following MDA are a major factor of poor... |
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Microfilariae of Wuchereria bancrofti in urine: an uncommon finding.
Diagn. Cytopathol. 39(11) , 847-8, (2011) Filariasis is a global health problem commonly seen in tropics and subtropics. Microfilariae has been reported in cytological specimens from various sites but is an unusual finding from sediments of centrifuged normally voided urine samples. This highlights t... |
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Acquired alpha 1-antitrypsin deficiency in tropical pulmonary eosinophilia.
Indian J. Med. Res. 134 , 79-82, (2011) Observation of an increased frequency of an intermediate deficiency of serum alpha1-antitrypsin (α1-AT) in patients with Tropical Pulmonary Eosinophilia (TPE) was earlier reported. Though the possibility of existence of an acquired deficiency was suggested, w... |
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Immunomodulatory activity of diethylcarbamazine on humoral, cellular cytokine response and respiratory burst in BALB/c mice.
Immunopharmacol. Immunotoxicol. 34(3) , 477-83, (2012) Diethylcarbamazine (DEC) is an anthelmintic piperazine derivative drug with putative immunomodulating properties, including increased platelet and granulocyte adhesion to parasites and enhanced production of cytokines. To further analyse these properties in a... |
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Effects of 5 rounds of mass drug administration with diethylcarbamazine and albendazole on filaria-specific IgG4 titers in urine: 6-year follow-up study in Sri Lanka.
Parasitol. Int. 60(4) , 393-7, (2011) ELISA for filaria-specific IgG4 in urine (urine ELISA) was applied to children in 7 schools in Sri Lanka, before and after 5 rounds of annual mass drug administration (MDA). The pre-treatment IgG4 prevalence in 2002 was 3.20%, which decreased to 0.91% in 2003... |