Glycyrrhetinic acid

Glycyrrhetinic acid Structure
Glycyrrhetinic acid structure
Common Name Glycyrrhetinic acid
CAS Number 471-53-4 Molecular Weight 470.684
Density 1.1±0.1 g/cm3 Boiling Point 588.3±50.0 °C at 760 mmHg
Molecular Formula C30H46O4 Melting Point 292 - 295ºC
MSDS N/A Flash Point 323.7±26.6 °C
Symbol GHS07
GHS07
Signal Word Warning

Hepatocellular carcinoma dually-targeted nanoparticles for reduction triggered intracellular delivery of doxorubicin.

Int. J. Pharm. 478(2) , 553-68, (2015)

Hepatocellular carcinoma (HCC) dual targeted stimuli responsive nanoparticles (NPs) for intracellular delivery of doxorubicin (DOX) were developed based on a reduction cleavable hyaluronic acid-glycyrrhetinic acid conjugate (HA-Cyst-GA). HA-Cyst-GA conjugate ...

Two-step inhibitory effect of kanzo on oxytocin-induced and prostaglandin F2α-induced uterine myometrial contractions.

J. Nat. Med. 68(3) , 550-60, (2014)

We previously reported that shakuyaku-kanzo-to, a kampo medicine consisting of shakuyaku and kanzo, has an inhibitory effect on myometrial contractions in pregnant women. In this study, we evaluated the effects of kanzo, glycyrrhizin (a major component of kan...

Prevention of cisplatin-induced ototoxicity by the inhibition of gap junctional intercellular communication in auditory cells. Kim YJ, Kim J, Tian C, et al.

Cell. Mol. Life Sci. 71(19) , 3859-71, (2014)

18β-glycyrrhetinic acid induces UDP-glucuronosyltransferase in rats.

Protein Pept. Lett. 20(12) , 1360-4, (2013)

UDP-glucuronosyltransferase (UDP) catalyzes a broad spectrum of endobiotic and xenobiotics. It is the isoform of the UGT1 family, which are made from the complex gene locus by an alternative combination of one of the unique first exons with the commonly used ...