3-nitro-L-tyrosine
3-nitro-L-tyrosine structure
|
Common Name | 3-nitro-L-tyrosine | ||
|---|---|---|---|---|
| CAS Number | 621-44-3 | Molecular Weight | 226.186 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 431.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C9H10N2O5 | Melting Point | 233-235ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 214.8±28.7 °C | |
|
Interferon-gamma induced cell death: Regulation and contributions of nitric oxide, cJun N-terminal kinase, reactive oxygen species and peroxynitrite.
Biochim. Biophys. Acta 1843(11) , 2645-61, (2014) Interferon-gamma (Ifnγ), a known immunomodulatory cytokine, regulates cell proliferation and survival. In this study, the mechanisms leading to the selective susceptibility of some tumor cells to Ifnγ were deciphered. Seven different mouse tumor cell lines te... |
|
|
Early redox imbalance is associated with liver dysfunction at weaning in overfed rats.
J. Physiol. 593 , 4799-811, (2015) Neonatal overfeeding induced by litter size reduction leads to further obesity and other metabolic disorders, such as liver oxidative stress and microsteatosis at adulthood. We hypothesized that overfeeding causes an early redox imbalance at weaning, which co... |
|
|
Epithelial MUC1 promotes cell migration, reduces apoptosis and affects levels of mucosal modulators during acetylsalicylic acid (aspirin)-induced gastropathy.
Biochem. J. 465(3) , 423-31, (2015) MUC1 is a transmembrane mucin highly expressed in the stomach. Although extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited. In the present study, we showed that acetylsalicylic acid... |
|
|
Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.
J. Mol. Cell. Cardiol. 77 , 42-52, (2015) Type 2 diabetes mellitus (T2DM)-induced cardiomyopathy is associated with cardiac oxidative stress, inflammation, and remodeling. Sulforaphane (SFN), an isothiocyanate naturally presenting in widely consumed vegetables, particularly broccoli, plays an importa... |
|
|
Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia.
Oncotarget 5(8) , 2052-64, (2014) Microenvironmental factors contribute to the immune dysfunction characterizing acute myeloid leukemia (AML). Indoleamine 2,3-dioxygenase 1 (IDO1) is an interferon (IFN)-γ-inducible enzyme that degrades tryptophan into kynurenine, which, in turn, inhibits effe... |
|
|
Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice.
Am. J. Physiol. Heart Circ. Physiol. 308 , H1126-35, (2015) Overnutrition/obesity predisposes individuals, particularly women, to diastolic dysfunction (DD), an independent predictor of future cardiovascular disease. We examined whether low-dose spironolactone (Sp) prevents DD associated with consumption of a Western ... |
|
|
Defective Human Sperm Cells Are Associated with Mitochondrial Dysfunction and Oxidant Production.
Biol. Reprod. 93 , 119, (2015) Infertility affects about 15% of couples of reproductive age. The male factor is involved in nearly 50% of infertility cases. Defective human sperm function has been associated with evidence of high levels of reactive oxygen species (ROS) and a resultant loss... |
|
|
Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice.
Am. J. Physiol. Renal Physiol. 308 , F981-92, (2015) Recently, we demonstrated in female mice that protection against ANG II-induced hypertension and associated cardiovascular changes depend on cytochrome P-450 (CYP)1B1. The present study was conducted to determine if Cyp1b1 gene disruption ameliorates renal dy... |
|
|
Cardioprotective effects of early and late aerobic exercise training in experimental pulmonary arterial hypertension.
Basic Res. Cardiol. 110 , 57, (2015) Clinical studies suggest that aerobic exercise can exert beneficial effects in pulmonary arterial hypertension (PAH), but the underlying mechanisms are largely unknown. We compared the impact of early or late aerobic exercise training on right ventricular fun... |
|
|
Sodium Butyrate Ameliorates L-Arginine-Induced Pancreatitis and Associated Fibrosis in Wistar Rat: Role of Inflammation and Nitrosative Stress.
J. Biochem. Mol. Toxicol. 29 , 349-59, (2015) Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is a short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of S... |