2-Hydroxyflutamide
2-Hydroxyflutamide structure
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Common Name | 2-Hydroxyflutamide | ||
|---|---|---|---|---|
| CAS Number | 52806-53-8 | Molecular Weight | 292.211 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 443.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C11H11F3N2O4 | Melting Point | 125-130℃ | |
| MSDS | Chinese USA | Flash Point | 222.2±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Metabolism of UV-filter benzophenone-3 by rat and human liver microsomes and its effect on endocrine-disrupting activity.
Toxicol. Appl. Pharmacol. 282(2) , 119-28, (2015) Benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is widely used as sunscreen for protection of human skin and hair from damage by ultraviolet (UV) radiation. In this study, we examined the metabolism of BP-3 by rat and human liver microsomes, and the es... |
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GATA3 in the urinary bladder: suppression of neoplastic transformation and down-regulation by androgens.
Am. J. Cancer Res. 4(5) , 461-73, (2014) Recent evidence suggests the involvement of sex hormone receptors in bladder cancer initiation, while precise functions of androgens and estrogens in the carcinogenesis step remain poorly understood. We recently found down-regulation of GATA3, a zinc-finger t... |
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TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells.
Oncotarget 6 , 17221-36, (2015) The cold and menthol receptor TRPM8 is highly expressed in prostate and prostate cancer (PC). Recently, we identified that TRPM8 is as an ionotropic testosterone receptor. The TRPM8 mRNA is expressed in early prostate tumors with high androgen levels, while a... |
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Engineered repressors are potent inhibitors of androgen receptor activity.
Oncotarget 5(4) , 959-69, (2014) Prostate cancer growth is dependent upon the Androgen Receptor (AR) pathway, hence therapies for this disease often target this signalling axis. Such therapies are successful in the majority of patients but invariably fail after a median of 2 years and tumour... |
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Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines.
PLoS ONE 6(8) , e23144, (2011) Prostate epithelial cells depend on androgens for survival and function. In (early) prostate cancer (PCa) androgens also regulate tumor growth, which is exploited by hormonal therapies in metastatic disease. The aim of the present study was to characterize th... |
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Improvement of neuronal bioenergetics by neurosteroids: implications for age-related neurodegenerative disorders.
Biochim. Biophys. Acta 1842(12 Pt A) , 2427-38, (2014) The brain has high energy requirements to maintain neuronal activity. Consequently impaired mitochondrial function will lead to disease. Normal aging is associated with several alterations in neurosteroid production and secretion. Decreases in neurosteroid le... |
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Medroxyprogesterone acetate enhances monocyte-endothelial interaction under flow conditions by stimulating the expression of cell adhesion molecules.
J. Clin. Endocrinol. Metab. 99(6) , 2188-97, (2014) Monocyte adhesion to endothelial cells is an important initial event in atherosclerosis and is partially mediated by adhesion molecule expression on the cell surface. Although estrogens inhibit atherosclerosis development, effects of coadministered progestoge... |
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Androgens inhibit aromatase expression through DAX-1: insights into the molecular link between hormone balance and Leydig cancer development.
Endocrinology 156(4) , 1251-62, (2015) Leydig cell tumors (LCTs) of the testis are steroid-secreting tumors associated with various steroid biosynthetic abnormalities and endocrine dysfunctions. Despite their overall rarity, LCTs are still of substantial interest owing to the paucity of informatio... |
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Fluorescence lifetime imaging microscopy for the monitoring of green fluorescent protein-tagged androgen receptors in living cells.
Chem. Pharm. Bull. 61(1) , 82-4, (2013) Fluorescence lifetime imaging microscopy (FLIM) was used to monitor the interaction between androgen receptor (AR) tagging of a green fluorescent protein (GFP) and the ligands in living cells. The fluorescence lifetime of the AR-GFP without ligands was ca. 3.... |
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The ability of the YAS and AR CALUX assays to detect the additive effects of anti-androgenic fungicide mixtures.
Toxicol. Lett. 241 , 193-9, (2015) Actual risk assessment only takes single pesticides into account, although about one third of the analyzed food samples in the European Union was contaminated with pesticide mixtures in 2013. A cumulative approach would group pesticides that share the same me... |