5-hydroxy Omeprazole
5-hydroxy Omeprazole structure
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Common Name | 5-hydroxy Omeprazole | ||
|---|---|---|---|---|
| CAS Number | 92340-57-3 | Molecular Weight | 361.41500 | |
| Density | 1.45g/cm3 | Boiling Point | 656.3ºC at 760mmHg | |
| Molecular Formula | C17H19N3O4S | Melting Point | 144-146ºC | |
| MSDS | Chinese USA | Flash Point | 350.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse.
Toxicol. Lett. 230(1) , 28-35, (2014) Drugs of abuse are not tested for cytochrome P450 (CYP) inhibition potential before distribution. Therefore, a cocktail assay should be developed for testing the inhibition potential for all relevant CYPs. The following CYP test substrates and selective inhib... |
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In vitro cytochrome P450 inhibition potential of methylenedioxy-derived designer drugs studied with a two-cocktail approach.
Arch. Toxicol. 90 , 305-18, (2016) In vitro cytochrome P450 (CYP) inhibition assays are common approaches for testing the inhibition potential of drugs for predicting potential interactions. In contrast to marketed medicaments, drugs of abuse, particularly the so-called novel psychoactive subs... |
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Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.
Toxicol. Lett. 241 , 82-94, (2015) New psychoactive substances (NPS) are not tested for their cytochrome P450 (CYP) inhibition potential before consumption. Therefore, this potential was explored for tryptamine-derived NPS (TDNPS) including alpha-methyl tryptamines (AMTs), dimethyl tryptamines... |
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A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug-drug interaction evaluation.
Xenobiotica 45 , 961-77, (2015) 1. A comprehensive method for the simultaneous characterization of xenobiotic compound inhibition of nine major CYP enzymes in human liver microsomes was established by using 16 CYP-catalyzed reactions of 14 probe substrates with three cocktail incubation set... |
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Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study.
Clin. Pharmacokinet. 55 , 79-91, (2016) Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of... |
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Pharmacokinetics of omeprazole and its metabolites in three phases of menstrual cycle.
Eur. J. Drug Metab. Pharmacokinet. 40(1) , 13-22, (2015) Omeprazole (OMP) is effective in the treatment of gastric hyperacidity and is metabolized by CYP2C19 and CYP3A4. These enzymes are modulated by estrogen and progesterone which regulate the menstrual cycle. The variations in the pharmacokinetics (PK) of many d... |
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Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.
Chem. Biol. Interact. 230 , 1-8, (2015) This study aimed to investigate the effects of five tanshinones, the lipophilic components from Danshen (Salvia miltiorrhiza), on CYP2C19 activity in pooled human liver microsomes (HLMs).The effects of tanshinones on CYP2C19 activity were compared by enzyme i... |
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Hydroxylation index of omeprazole in relation to CYP2C19 polymorphism and sex in a healthy Iranian population.
Daru 22 , 81, (2014) Polymorphism of CYP2C19 gene is one of the important factors in pharmacokinetics of CYP2C19 substrates. Omeprazole is a proton pump inhibitor which is mainly metabolized by cytochrome P450 2C19 (CYP2C19). The aim of present study was to assess omeprazole hydr... |
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High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 895-896 , 56-64, (2012) A sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method with electrospray ionization was developed for the simultaneous quantitation of five probe drugs and their metabolites in human plasma for assessing the in vivo activities of cytoch... |
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Inhibitory effect of oral contraceptives on CYP2C19 activity is not significant in carriers of the CYP2C19*17 allele.
Clin. Exp. Pharmacol. Physiol. 40(10) , 683-8, (2013) (1) The purpose of the present study was to examine whether cytochrome P450 2C19 (CYP2C19) in carriers of the CYP2C19*17 allele is inhibited in vivo by oral contraceptives (OC). (2) Retrospective CYP2C19 phenotyping according to omeprazole : 5-OH-omeprazole m... |