temazepam
temazepam structure
|
Common Name | temazepam | ||
|---|---|---|---|---|
| CAS Number | 846-50-4 | Molecular Weight | 300.74000 | |
| Density | 1.34g/cm3 | Boiling Point | 549.9ºC at 760 mmHg | |
| Molecular Formula | C16H13ClN2O2 | Melting Point | 119-121ºC | |
| MSDS | Chinese USA | Flash Point | 11ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).
Forensic Sci. Int. 243 , 99-106, (2014) The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-residue pesticide analysis in food and agricultural products. ... |
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A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case.
Forensic Sci. Int. 243 , 149-55, (2014) We report on a case of repeated MDPV consumptions that resulted in severe psychosis and agitation prompting the concomitant abuse of benzodiazepines. A 27-year-old man was found irresponsive in his apartment and was brought to the emergency department (ED) of... |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry.
Sci. Total Environ. 511 , 153-60, (2015) The development, characterisation and application of a new analytical method for multi-residue PPCP determination in the freshwater amphipod, Gammarus pulex are presented. Analysis was performed using pulverised liquid extraction (PuLE), solid phase extractio... |
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Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay.
Ann. Clin. Biochem. 47(Pt 2) , 111-7, (2010) Liquid chromatography linked to tandem mass spectrometry (LC/MS/MS) provides the ability to identify a range of benzodiazepines in accordance with European Union criteria and is an attractive method for the confirmation of benzodiazepines following immunoassa... |
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UDP-glucuronosyltransferases and clinical drug-drug interactions.
Pharmacol. Ther. 106 , 97-132, (2005) UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various endogenous substances (e.g., bilirubin) and exogenous compounds (e.g., drugs). The human UGT superfamily is comprised of 2 families (UGT1 and UGT2) and 3 subfamilies (UGT1A, UGT2A, ... |
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Computational aqueous solubility prediction for drug-like compounds in congeneric series.
Eur. J. Med. Chem. 43 , 501-12, (2008) It was the aim of the present work to develop a quantitative structure-property relationship (QSPR) model for predicting the aqueous solubility of drug-like compounds in congeneric series. Lipophilicity combined with structural fragment information, fragmenta... |
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An in vitro approach to estimate putative inhibition of buprenorphine and norbuprenorphine glucuronidation.
Int. J. Legal Med. 124(3) , 187-94, (2010) An in vitro inhibition study was performed to investigate potential drug-drug interactions on glucuronidation of buprenorphine (BUP) and norbuprenorphine (NBUP), which represents the major elimination pathway of the drug using cDNA-expressed uridine 5'-diphos... |