halopemide
halopemide structure
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Common Name | halopemide | ||
|---|---|---|---|---|
| CAS Number | 59831-65-1 | Molecular Weight | 416.876 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H22ClFN4O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation.
Purinergic Signal. 9(4) , 609-19, (2013) The P2X7 receptor is a trimeric ATP-gated cation channel important in health and disease. We have observed that the specific phospholipase D (PLD)1 antagonist, CAY10593 impairs P2X7-induced shedding of the 'low affinity' IgE receptor, CD23. The current study ... |
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Halopemide, a new psychotropic agent. Cerebral distribution and receptor interactions.
Pharm. Weekbl. Sci. 7(1) , 1-9, (1985) Halopemide is a new psychotropic agent, a structural analogue of the neuroleptics of the butyrophenone type but with different pharmacological and clinical properties. Preliminary clinical findings indicate that halopemide lacks the ability to induce parkinso... |
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Dynamic cation-exchange systems for the separation of drugs derived from butyrophenone and diphenylpiperidine by high-performance liquid chromatography and applied in the determination of halopemide in plasma.
J. Chromatogr. A. 164(2) , 177-85, (1979) Dynamic (solvent generated) cation-exchange systems for the separation of drugs and main metabolites derived from butyrophenone and diphenylpiperidine (haloperidol, pimozide, halopemide) were investigated. The effect of organic modifier, detergent, counter-io... |
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Endocrine effects of domperidone: a peripheral dopamine blocking agent.
Clin. Endocrinol. (Oxf.) 15(3) , 275-82, (1981) In the present study, effects of domperidone, a peripheral dopamine blocking agent, on prolactin and growth hormone were examined to determine whether dopamine regulation of these hormones involved structures external to the blood-brain barrier. A clearcut el... |
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Effects of halopemide on potassium-induced release of radiolabeled neurotransmitters from rat cerebrocortical slices in vitro.
Arch. Int. Pharmacodyn. Ther. 247(1) , 43-58, (1980) The effects of halopemide on the release of 3H-serotonin, 3H-noradrenaline, 3H-acetylcholine and 3H-GABA from rat frontal cortical slices in vitro were studied and compared to those of its neuroleptic congener R29800, spiperone and haloperidol. Spontaneous 3H... |
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Bromocriptine and apomorphine stimulation of cortisol secretion in conscious dogs; evidence for a stimulatory site located outside the blood brain barrier.
Psychopharmacology 89(1) , 108-12, (1986) IV injections of the dopamine receptor agonists bromocriptine (0.1 mg/kg) and apomorphine (0.05 mg/kg) induced rapid and long-lasting increases of cortisol levels as measured by RIA in peripheral venous plasma of conscious dogs. Pretreatment with dopamine rec... |
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Effects of dopamine receptor antagonists on gastrin and vomiting responses to apomorphine.
Naunyn Schmiedebergs Arch. Pharmacol. 336(1) , 16-9, (1987) Apomorphine (0.05 mg/kg intravenously) was given to conscious dogs, and gastrin levels were measured in peripheral venous blood with a radioimmunoassay. Apomorphine induced an increase of gastrin levels which peaked at 5 min. The peripheral dopamine D-2/DA2 r... |
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Effects of halopemide on GABA receptor binding, uptake and release.
Brain Res. 210(1-2) , 485-92, (1981)
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Acute dyskinesias in monkeys elicited by halopemide, mezilamine and the "antidyskinetic" drugs, oxiperomide and tiapride.
Psychopharmacology 75(3) , 254-7, (1981) Oxiperomide and tiapride are dopamine receptor antagonists claimed to have "antidyskinetic" properties in animal models and the clinic. Halopemide and mezilamine are other dopamine antagonists predicted to lack extrapyramidal side effects in man on the basis ... |
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Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment.
Eur. Arch. Psychiatry Clin. Neurosci. 254(5) , 318-25, (2004) In vitro, animal studies and acute short-term clinical studies suggest clozapine releases prolactin but the effect is much smaller than that of typical antipsychotics. Repeated early morning trough measures of plasma clozapine and prolactin levels on each sub... |