2-methyl-2-phenylsuccinimide
2-methyl-2-phenylsuccinimide structure
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Common Name | 2-methyl-2-phenylsuccinimide | ||
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| CAS Number | 1497-17-2 | Molecular Weight | 189.21100 | |
| Density | 1.179g/cm3 | Boiling Point | 371.1ºC at 760mmHg | |
| Molecular Formula | C11H11NO2 | Melting Point | 83-85ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 165.3ºC | |
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Anticonvulsants Based on the α-Substituted Amide Group Pharmacophore Bind to and Inhibit Function of Neuronal Nicotinic Acetylcholine Receptors.
ACS Chem. Neurosci. 7 , 316-26, (2016) Although the antiepileptic properties of α-substituted lactams, acetamides, and cyclic imides have been known for over 60 years, the mechanism by which they act remains unclear. I report here that these compounds bind to the nicotinic acetylcholine receptor (... |
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Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.
Br. J. Pharmacol. 100(4) , 800-6, (1990) 1. Succinimide derivatives can be either convulsant (tetramethylsuccinimide (TMS)), or anticonvulsant (ethosuximide (ES); alpha-methyl-alpha-phenylsuccinimide (MPS)). ES, an anticonvulsant succinimide, has previously been shown to block calcium currents of th... |
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Block of cloned human T-type calcium channels by succinimide antiepileptic drugs.
Mol. Pharmacol. 60(5) , 1121-32, (2001) Inhibition of T-type Ca(2+) channels has been proposed to play a role in the therapeutic action of succinimide antiepileptic drugs. Despite the widespread acceptance of this hypothesis, recent studies using rat and cat neurons have failed to confirm inhibitio... |
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Improved isocratic liquid-chromatographic simultaneous measurement of phenytoin, phenobarbital, primidone, carbamazepine, ethosuximide, and N-desmethylmethsuximide in serum.
Clin. Chem. 28(1) , 100-4, (1982) We describe an improved "high-pressure" liquid-chromatographic assay for simultaneous determination in serum of the five major antiepileptic drugs (ethosuximide, primidone, phenobarbital, phenytoin, and carbamazepine) and N-desmethylmethsuximide (the compound... |
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Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade.
Br. J. Pharmacol. 100(4) , 807-13, (1990) 1. Currents evoked by applications of gamma-aminobutyric acid (GABA) to acutely dissociated thalamic neurones were analysed by voltage-clamp techniques, and the effects of the anticonvulsant succinimides ethosuximide (ES) and alpha-methyl-alpha-phenylsuccinim... |
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Transient enhancement of low-threshold calcium current in thalamic relay neurons after corticectomy.
J. Neurophysiol. 70(1) , 20-7, (1993) 1. The alterations of voltage-sensitive calcium currents produced in thalamic cells by injury were investigated under voltage clamp using patch-clamp recordings in the whole-cell configuration. 2. One day after unilateral cortical ablation in immature rats (p... |
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Methsuximide for intractable childhood seizures.
Pediatrics 87(2) , 186-9, (1991) Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy. In 15 patients the drug was well tolerated and resulted in a 50% or greater reduction in seizure frequency. No serious or irreversible adverse effects were seen. Meth... |
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Quantitative simultaneous determination of eight common antiepileptic drugs and metabolites by liquid chromatography.
Ther. Drug Monit. 3(4) , 397-413, (1981) Specific antiepileptic drug (AED) concentrations in serum are believed to cause therapeutic effects in individual patients. Communication between the clinician and the laboratory performing the drug level determinations is therefore essential for safe and eff... |
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Pharmacokinetics of N-desmethylmethsuximide in pediatric patients.
J. Pediatr. 114(4 Pt 1) , 647-50, (1989)
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Determination of N-desmethylmethsuximide serum concentrations using enzyme-multiplied and fluorescence polarization immunoassays.
Ther. Drug Monit. 11(3) , 337-42, (1989) N-Desmethylmethsuximide (NDM), the active metabolite of the antiepileptic agent methsuximide, has been analyzed by gas-liquid chromatography and high-performance liquid chromatography (HPLC) in the past. This study compares methods using two commercially avai... |