Quinidine sulfate dihydrate
Quinidine sulfate dihydrate structure
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Common Name | Quinidine sulfate dihydrate | ||
|---|---|---|---|---|
| CAS Number | 6591-63-5 | Molecular Weight | 782.943 | |
| Density | N/A | Boiling Point | 992.5ºC at 760 mmHg | |
| Molecular Formula | C20H24N2O2.1/2H2O4S.H2O | Melting Point | 212-214 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 554ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.
Antimicrob. Agents Chemother. 58(6) , 3168-76, (2014) Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS c... |
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Diurnal variation in P-glycoprotein-mediated transport and cerebrospinal fluid turnover in the brain.
AAPS J. 16(5) , 1029-37, (2014) Nearly all bodily processes exhibit circadian rhythmicity. As a consequence, the pharmacokinetic and pharmacodynamic properties of a drug may also vary with time of day. The objective of this study was to investigate diurnal variation in processes that regula... |
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Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys.
Biopharm. Drug Dispos. 36(1) , 15-33, (2015) Aliskiren is a substrate for P-glycoprotein (P-gp) and is metabolized via cytochrome P450 3A4 (CYP3A4). The aim of the present study was to assess whether P-gp influenced the pharmacokinetics of aliskiren and also if drug-drug interactions (DDIs) mediated thr... |
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Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.
Eur. J. Pediatr. 174(4) , 509-18, (2015) This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONME... |
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Application of MS Transport Assays to the Four Human γ-Aminobutyric Acid Transporters.
ChemMedChem 10 , 1498-510, (2015) γ-Aminobutyric acid (GABA) transporters (GATs) are promising drug targets for various diseases associated with imbalances in GABAergic neurotransmission. For the development of new drugs or pharmacological tools addressing GATs, screening techniques to identi... |
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Magnesium and selected parameters of the non-enzymatic antioxidant and immune systems and oxidative stress intensity in the seminal plasma of fertile males.
Magnes. Res. 28 , 14-22, (2015) The present study investigated associations between environmental exposure to magnesium (Mg) and the levels of oxidative stress parameters and selected cytokines, and the antioxidant defense system in the seminal plasma of fertile males.The study population c... |
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Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate.
Xenobiotica 44(11) , 1039-45, (2014) 1. This study was aimed to characterize gastrointestinal absorption of digoxin using wild-type (WT) and multidrug resistance protein 1a [mdr1a; P-glycoprotein (P-gp)] knockout (-/-) rats. 2. In WT rats, the area under the plasma concentration-time curve (AU... |
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Multi-matrix assay of the first melatonergic antidepressant agomelatine by combined liquid chromatography-fluorimetric detection and microextraction by packed sorbent
J. Pharm. Biomed. Anal. 95 , 61-7, (2014) A rapid and reliable analytical method has been developed to quantify the melatonergic antidepressant agomelatine in three matrices, and namely saliva, plasma and dried blood spots. The method is based on the use of liquid chromatography with fluorimetric det... |