trans,trans-Muconic Acid
trans,trans-Muconic Acid structure
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Common Name | trans,trans-Muconic Acid | ||
|---|---|---|---|---|
| CAS Number | 3588-17-8 | Molecular Weight | 142.109 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 345.4±15.0 °C at 760 mmHg | |
| Molecular Formula | C6H6O4 | Melting Point | 290 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 176.9±16.9 °C | |
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Influence of genetic polymorphism on t,t-MA/S-PMA ratio in 301 benzene exposed subjects.
Toxicol. Lett. 231(2) , 205-12, (2014) This study investigated the effect of polymorphic genes GSTT1, GSTM1, GSTA1, EHPX1, NQO1, CYP2E1, CYP1A and MPO on the urinary concentrations and ratio (R) of the benzene metabolites trans,trans-muconic acid (t,t-MA) and S-phenyl mercapturic acid (S-PMA) in 3... |
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Quantitative analysis of catechol and 4-methylcatechol in human urine.
Food Chem. Toxicol. 20(5) , 587-90, (1982) A method was developed for the quantitative analysis of catechol and 4-methylcatechol in human urine. [U-14C]Catechol was used as in internal standard. Urine was treated with beta-glucuronidase and sulphatase, acidified and extracted with ether. The ether ext... |
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Almond consumption reduces oxidative DNA damage and lipid peroxidation in male smokers.
J. Nutr. 137(12) , 2717-22, (2007) Smoking increases the risk of several chronic diseases associated with elevated oxidative stress status. Almonds are a good source of antioxidant nutrients and may diminish smoking-related biomarkers of oxidative stress. We investigated whether almond consump... |
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Simultaneous determination of mercapturic acids derived from ethylene oxide (HEMA), propylene oxide (2-HPMA), acrolein (3-HPMA), acrylamide (AAMA) and N,N-dimethylformamide (AMCC) in human urine using liquid chromatography/tandem mass spectrometry.
Rapid Commun. Mass Spectrom. 22(17) , 2629-38, (2008) Mercapturic acids are highly important and specific biomarkers of exposure to carcinogenic substances in occupational and environmental medicine. We have developed and validated a reliable, specific and very sensitive method for the simultaneous determination... |
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Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct.
Toxicol. Lett. 155(3) , 403-10, (2005) 5-Hydroxymethyluracil (5-HMU) is derived from radiation in addition to endogenous oxidative DNA damage and it is one of the most abundant DNA adducts. Human 5-HMU-DNA-glycosylase has been shown to repair this lesion. Whether urinary levels of 5-HMU is a valid... |
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Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokers
J. Pharm. Biomed. Anal. 49(1) , 129-32, (2009) A simple, rapid and sensitive liquid chromatography/mass spectrometry (LC/MS) method has been utilized for the quantitative determination of nicotine and its major metabolite cotinine (COT) in human cerebrospinal fluid (CSF) of active and passive smokers. CSF... |
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A single-step extraction method for the determination of nicotine and cotinine in Jordanian smokers' blood and urine samples by RP-HPLC and GC-MS.
J. Chromatogr. Sci. 47(2) , 170-7, (2009) A simple, rapid, reliable, and low cost one-step extraction method is developed and validated for the determination of nicotine and cotinine in human plasma and urine in smokers using reversed-phase high-performance liquid chromatography (RP-HPLC) and gas chr... |
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Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles.
Clin. Chem. 48(9) , 1460-71, (2002) Assessment of nicotine metabolism and disposition has become an integral part of nicotine dependency treatment programs. Serum nicotine concentrations or urine cotinine concentrations can be used to guide nicotine patch dose to achieve biological concentratio... |
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Tetrahydrobiopterin restores endothelial function in long-term smokers.
J. Am. Coll. Cardiol. 35(1) , 71-5, (2000) We sought to test whether tetrahydrobiopterin (BH4) supplementation improves nitric oxide (NO) bioactivity in smokers.In smokers, endothelium-derived NO bioactivity is impaired. BH4 is an essential cofactor of NO synthase, and its deficiency decreases NO bioa... |
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Determination of nicotine and four metabolites in the serum of smokers by high-performance liquid chromatography with ultraviolet detection.
J. Chromatogr. A. 621(2) , 257-61, (1993) A simple and reliable reversed-phase high-performance liquid chromatographic method with ultraviolet detection is described for the quantitation of nicotine and its metabolites cotinine, trans-3'-hydroxycotinine, norcotinine and cotinine N-oxide in human seru... |