orphenadrine citrate
orphenadrine citrate structure
|
Common Name | orphenadrine citrate | ||
|---|---|---|---|---|
| CAS Number | 4682-36-4 | Molecular Weight | 461.50500 | |
| Density | 1.014 g/cm3 | Boiling Point | 363ºC at 760 mmHg | |
| Molecular Formula | C24H31NO8 | Melting Point | 132-134ºC | |
| MSDS | Chinese USA | Flash Point | 107.1ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
|
Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs.
Exp. Neurol. 255 , 96-102, (2014) Although the sodium channel blocker mexiletine is considered the first-line drug in myotonia, some patients experiment adverse effects, while others do not gain any benefit. Other antimyotonic drugs are thus needed to offer mexiletine alternatives. In the pre... |
|
|
Spectrophotometric determination of tizanidine and orphenadrine via ion pair complex formation using eosin Y.
Chem. Cent. J. 5 , 60, (2011) A simple, sensitive and rapid spectrophotometric method was developed and validated for the determination of two skeletal muscle relaxants namely, tizanidine hydrochloride (I) and orphenadrine citrate (II) in pharmaceutical formulations. The proposed method i... |
|
|
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study.
Audiol. Neurootol. 17(3) , 179-88, (2012) Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study ... |
|
|
Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.
Naunyn Schmiedebergs Arch. Pharmacol. 376(4) , 275-84, (2007) The anticholinergic antiparkinson drug orphenadrine is an antagonist at central and peripheral muscarinic receptors. Orphenadrine intake has recently been linked to QT prolongation and Torsade-de-Pointes tachycardia. So far, inhibitory effects on I (Kr) or cl... |
|
|
Validated stability-indicating reversed-phase-HPLC method for simultaneous determination of orphenadrine citrate, caffeine and aspirin.
Chem. Pharm. Bull. 60(11) , 1426-36, (2012) New, simple, rapid and precise reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of orphenadrine citrate, caffeine and aspirin in presence of aspirin degradation products, orphenadrine citrate and c... |
|
|
Pharmacokinetic, metabolism and withdrawal time of orphenadrine in camels (Camelus dromedarius) after intravenous administration.
Res. Vet. Sci. 85(3) , 563-9, (2008) The pharmacokinetics of orphenadrine (ORPH) following a single intravenous (i.v.) dose was investigated in six camels (Camelus dormedarius). Orphenadrine was extracted from the plasma using a simple sensitive liquid-liquid extraction method and determined by ... |
|
|
Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.
J. Pharm. Pharmacol. 61(1) , 47-54, (2009) It has been reported that the non-renal clearance of furosemide was significantly faster in rats pretreated with phenobarbital but was not altered in rats pretreated with 3-methylcholanthrene. However, no studies on other cytochrome P450 (CYP) isozymes have y... |
|
|
Influence of orphenadrine upon the protective activity of various antiepileptics in the maximal electroshock-induced convulsions in mice.
Pharmacol. Rep. 61(4) , 732-6, (2009) Orphenadrine is an anticholinergic drug used in the treatment of Parkinson's disease, and is also known to exert nonspecific antagonistic activity at the phencyclidine binding site of the N-methyl-D-aspartate (NMDA) receptor. The aim of this study was to asse... |
|
|
Anticholinergic drug-induced delirium in an elderly Alzheimer's dementia patient.
Arch. Gerontol. Geriatr. 44 Suppl 1 , 199-206, (2007) Drug-induced delirium is a common matter in the elderly and anticholinergics, together with a number of different drugs, may significantly contribute to the delirium onset, especially in demented people. We report a case of a probable anticholinergic drug-ind... |
|
|
Orphenadrine induces secondarily generalized convulsive status epilepticus in rats.
Brain Res. Bull. 84(6) , 389-93, (2011) The current study was aimed to assess the convulsant potency of orphenadrine (ORPH) in rats together with a screen of different conventional antiepileptic drugs (AEDs) on their efficacy to suppress it. ORPH was administered intraperitoneally (i.p.) in doses o... |