4-Chloro-3,5-dinitrobenzoic acid

4-Chloro-3,5-dinitrobenzoic acid Structure
4-Chloro-3,5-dinitrobenzoic acid structure
Common Name 4-Chloro-3,5-dinitrobenzoic acid
CAS Number 118-97-8 Molecular Weight 246.561
Density 1.8±0.1 g/cm3 Boiling Point 422.7±45.0 °C at 760 mmHg
Molecular Formula C7H3ClN2O6 Melting Point 159-162 °C(lit.)
MSDS Chinese USA Flash Point 209.4±28.7 °C
Symbol GHS07
GHS07
Signal Word Warning

The modulation of cytochrome c electron self-exchange by site-specific chemical modification and anion binding.

FEBS Lett. 206(1) , 15-9, (1986)

The site-specific chemical modification of horse heart cytochrome c at Lys-13 and -72 using 4-chloro-3,5-dinitrobenzoic acid (CDNB) increases the electron self-exchange rate of the protein. In the presence of 0.24 M cacodylate (pH* 7.0) the electron self-exch...

Localization of lysine residues in the binding domain of the K99 fibrillar subunit of enterotoxigenic Escherichia coli.

Biochim. Biophys. Acta 872(1-2) , 92-7, (1986)

Modification of lysine residues with 4-chloro-3,5-dinitrobenzoate results in the loss of the binding capacity of K99 fibrillae to horse erythrocytes (Jacobs, A.A.C., van Mechelen, J.R. and de Graaf, F.K. (1985) Biochim. Biophys. Acta 832, 148-155). In the pre...

Threshold levels in toxicology: significance of inactivation mechanisms.

Adv. Exp. Med. Biol. 136 Pt B , 1389-98, (1981)

Metabolic inactivation of chemicals may prevent toxic effects of reactive intermediates when present at low levels whereas inactivation may be overcome at high levels changing dose-effect relation. This is demonstrated in various in vitro test systems: a) Mon...

Chemical modification of spinach plastocyanin using 4-chloro-3,5-dinitrobenzoic acid: characterization of four singly-modified forms.

Biochim. Biophys. Acta 1016(1) , 107-14, (1990)

Chemical modification of plastocyanin was carried out using 4-chloro-3,5-dinitrobenzoic acid, which has the effect of replacing positive charges on amino groups with negatively charged carboxyl groups. Four singly-modified forms were obtained which were separ...

Chemical modification of amino groups in cardiotoxin III from Taiwan cobra Naja naja atra) venom.

Biochem. Mol. Biol. Int. 31(1) , 175-84, (1993)

Cardiotoxin III (CTX III), a major cardiotoxin analogue isolated from the Taiwan cobra (Naja naja atra) venom was modified, either with trinitrobenzene sulfonate (TNBS) or 4-chloro-3,5-dinitrobenzoate (CDNB). Under the conditions of limited reagent availabili...

Enzymatic dehalogenation of chlorinated nitroaromatic compounds.

Appl. Environ. Microbiol. 54(5) , 1199-202, (1988)

4-Chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS3 converted 4-chloro-3,5-dinitrobenzoate to 3,5-dinitro-4-hydroxybenzoate and 1-chloro-2,4-dinitrobenzene to 2,4-dinitrophenol. The activities were 0.13 mU/mg of protein for 4-chloro-3,5-dinitrobenz...

Chemical modification of Lys-6 in Taiwan cobra phospholipase A2 with 4-chloro-3,5-dinitrobenzoate.

Biochem. Mol. Biol. Int. 33(6) , 1207-13, (1994)

Phospholipase A2 (PLA2) from Naja naja atra snake venom was modified with 4-chloro-3,5-dinitrobenzoate, and one major carboxydinitrophenylated (CDNP) PLA2 was separated by high performance liquid chromato-graphy. CDNP-PLA2 contained only one CDNP group on Lys...

Physicochemical and toxicological studies on 4-chloro-3,5-dinitrobenzoic acid in aqueous solutions.

Environ. Toxicol. Chem. 23(5) , 1129-35, (2004)

Physicochemical characterization of hazardous compounds often is required for the development of structure-reactivity correlations. Physical, chemical, and toxicological properties of target pollutants require determination for an efficient application of was...