Brimonidine
Brimonidine structure
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Common Name | Brimonidine | ||
|---|---|---|---|---|
| CAS Number | 59803-98-4 | Molecular Weight | 292.135 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 432.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C11H10BrN5 | Melting Point | 207.5 °C | |
| MSDS | Chinese USA | Flash Point | 215.4±31.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity.
PLoS ONE 10 , e0141327, (2015) The search for drugs with anorectic activity, acting within the adrenergic system has attracted the interest of researchers. Partial α2-adrenoceptor agonists might offer the potential for effective and safe treatment of obesity. We compared the effectiveness ... |
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Brimonidine reduces TGF-beta-induced extracellular matrix synthesis in human Tenon's fibroblasts.
BMC Ophthalmol. 15 , 54, (2015) Brimonidine is a highly selective α2 adrenergic agonist that has been widely used in anti-glaucoma eyedrops. The aim of this study was to investigate its putative anti-fibrotic role in the fibrosis caused by activated Tenon's fibroblasts.Primary cultured huma... |
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Dilute brimonidine to improve patient comfort and subconjunctival hemorrhage after LASIK.
J. Refract. Surg. 29(7) , 469-75, (2013) To investigate whether dilute brimonidine (0.025%) reduces patient discomfort, subconjunctival hemorrhage, and injection after LASIK without a significant increase in the rate of flap complications or surgical enhancements.This randomized, double-blind, prosp... |
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Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.
FASEB J. 29 , 2194-204, (2015) Reactive oxygen species play an important role in the pathogenesis of diabetic retinopathy. We studied the role of adrenergic and serotonin receptors in the generation of superoxide by retina and 661W retinal cells in high glucose and of the α1-adrenergic rec... |
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Rosacea: update on management and emerging therapies.
Skin Therapy Lett. 17(10) , 1-4, (2012) Rosacea is a common chronic skin disorder that has significant impact on the self-esteem and quality of life of affected individuals. Currently understood as an inflammatory condition that occurs in the context of an altered innate immune response, the availa... |
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Comparison of the Progression Rates of the Superior, Inferior, and Both Hemifield Defects in Normal-Tension Glaucoma Patients
Am. J. Ophthalmol. 154(6) , 958-968.e1, (2012) Purpose To investigate the progression rates of superior and inferior hemifield defects and each hemifield in bihemifield defects in normal-tension glaucoma patients and to compare the progression rates of each hemifield between groups in eyes with similar ba... |
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Bleb Analysis and Short-Term Results of Biodegradable Collagen Matrix-Augmented Ahmed Glaucoma Valve Implantation: 6-Month Follow-up.
Invest. Ophthalmol. Vis. Sci. 56 , 5896-903, (2015) To evaluate the short-term efficacy of a biodegradable collagen matrix (BCM) as an adjuvant for Ahmed valve implantation surgery to prevent the hypertensive phase.This prospective study included 43 refractory glaucoma eyes, all followed for 6 months. Refracto... |
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Ability of Bottle Cap Color to Facilitate Accurate Patient-Physician Communication Regarding Medication Identity in Patients with Glaucoma.
Ophthalmology 122 , 2373-9, (2015) To determine the accuracy of patient-physician communication regarding topical ophthalmic medication use based on bottle cap color, particularly among individuals who may have acquired color vision deficiency from glaucoma.Cross-sectional, clinical study.Pati... |
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Brinzolamide/brimonidine (Simbrinza) for glaucoma.
Med. Lett. Drugs Ther. 55(1421) , 57-8, (2013)
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Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma.
Invest. Ophthalmol. Vis. Sci. 53(7) , 3733-41, (2012) To characterize the microbead-induced ocular hypertension (OHT) mouse model and investigate its potential use for preclinical screening and evaluation of ocular hypotensive agents, we tested the model's responses to major antiglaucoma drugs.Adult C57BL/6J mic... |