Tazarotene
Tazarotene structure
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Common Name | Tazarotene | ||
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| CAS Number | 118292-40-3 | Molecular Weight | 351.462 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 499.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C21H21NO2S | Melting Point | 97-98ºC | |
| MSDS | Chinese USA | Flash Point | 256.1±28.7 °C | |
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A custom tailored model to investigate skin penetration in porcine skin and its comparison with human skin.
Eur. J. Pharm. Biopharm. 95 , 99-109, (2015) Reliable models for the determination of skin penetration and permeation are important for the development of new drugs and formulations. The intention of our study was to develop a skin penetration model which (1) is viable and well supplied with nutrients d... |
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Tazarotene versus tretinoin or adapalene in the treatment of acne vulgaris.
J. Am. Acad. Dermatol. 43(2 Pt 3) , S51-4, (2000) The efficacy and tolerability of tazarotene 0.1% gel in the treatment of acne vulgaris have been compared with those of tretinoin 0.025% gel and adapalene 0.1% gel in multicenter, double-blind, randomized, parallel-group trials. Preliminary results from the t... |
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Retinoic acid receptor signaling preserves tendon stem cell characteristics and prevents spontaneous differentiation in vitrox.
Stem Cell Res. Ther. 7 , 45, (2016) Previous studies have reported that adult mesenchymal stem cells (MSCs) tend to gradually lose their stem cell characteristics in vitro when placed outside their niche environment. They subsequently undergo spontaneous differentiation towards mesenchymal line... |
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Improving outcomes in patients with psoriasis.
Practitioner 257(1757) , 27-30, 3, (2013) Psoriasis is a heterogeneous inflammatory disorder that targets the skin and joints. It affects 1.3-2% of the population. The diagnosis of plaque psoriasis is usually straightforward, a helpful diagnostic clue is the tendency for silver scales to appear after... |
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Clindamycin phosphate 1.2%-benzoyl peroxide (5% or 2.5%) plus tazarotene cream 0.1% for the treatment of acne.
Cutis. 91(2) , 99-104, (2013) Acne is a multifactorial chronic dermatosis that can be effectively treated with adjuvant medications. The objective of our study was to compare the tolerability and efficacy of 2 adjuvant therapies combining clindamycin phosphate 1.2%-benzoyl peroxide 5% (CL... |
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Phototoxic and photoallergic potential of tazarotene foam 0.1% in 2 phase 1 patch studies.
Cutis. 90(5) , 266-71, (2012) Two phase 1 patch studies were conducted to evaluate tazarotene foam 0.1% for phototoxic (study A) and photoallergic (study B) potential. In study A, 38 participants were exposed to patches containing tazarotene foam 0.1%, vehicle foam, or no foam (blank patc... |
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Topical tazarotene for the treatment of ectropion in ichthyosis.
JAMA Dermatol. 149(5) , 598-600, (2013) Ectropion is a complication of certain subtypes of ichthyosis and is often associated with substantial medical and cosmetic consequences. At present there is no standard of care for the treatment of ectropion in this population. Retinoids cause dyshesion and ... |
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An erythematous papular lesion on the neck of a young boy. Elastosis perforans serpiginosa.
Pediatr. Dermatol. 29(5) , 659-60, (2012)
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Do lasers or topicals really work for nonmelanoma skin cancers?
Semin. Cutan. Med. Surg. 30(1) , 14-25, (2011) Novel strategies are urgently needed to address the millions of nonmelanoma skin cancers treated in the United States annually. The need is greatest for those patients who are poor surgical candidates or those prone to numerous nonmelanoma skin cancers and th... |
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The role of tazarotene in the treatment of psoriasis.
Br. J. Dermatol. 140 Suppl 54 , 24-8, (1999) The recent availability of tazarotene, the first receptor-selective retinoid, provides a much-needed addition to the therapeutic armamentarium for mild-to-moderate plaque psoriasis. Tazarotene gel offers a welcome combination of good efficacy and cosmetic acc... |