Propionamide
Propionamide structure
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Common Name | Propionamide | ||
|---|---|---|---|---|
| CAS Number | 79-05-0 | Molecular Weight | 73.094 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 103.0±23.0 °C at 760 mmHg | |
| Molecular Formula | C3H7NO | Melting Point | 79 °C | |
| MSDS | Chinese USA | Flash Point | 16.1±22.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells.
Pharm. Biol. 53(4) , 540-7, (2015) Glycosmis parva Craib (Rutaceae) is reported to have cytotoxic and anti-inflammatory activities by decreasing COX-2 expression.To investigate the effect of G. parva on human colorectal cancer cells expressing COX-2, HT-29 cells.HT-29 cells were treated with e... |
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Gamma secretase inhibitors enhance vincristine-induced apoptosis in T-ALL in a NOTCH-independent manner.
Apoptosis 19(11) , 1616-26, (2014) Activating mutations in the NOTCH1 gene are found in over 50 % of T-ALL cases. Since Notch signaling contributes to the leukemia cell survival and growth, targeting Notch signaling using γ-secretase inhibitors (GSI) has been proposed as a molecularly targeted... |
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Mass spectrometric characterization of glucuronides formed by a new concept, combining Cunninghamella elegans with TEMPO.
J. Pharm. Biomed. Anal. 84 , 278-84, (2013) A new concept for the production of drug glucuronides is presented and the products formed were characterized using ultra high performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). Glucuronic acid conjugates are important phase II m... |
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The effects of exercise on synaptic stripping require androgen receptor signaling.
PLoS ONE 9(6) , e98633, (2014) Following peripheral nerve injury, synapses are withdrawn from axotomized motoneurons. Moderate daily treadmill exercise, which promotes axon regeneration of cut peripheral nerves, also influences this synaptic stripping. Different exercise protocols are requ... |
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A microreactor for the study of biotransformations by a cross-linked gamma-lactamase enzyme.
Biotechnol. J. 4(4) , 510-6, (2009) A (+)-gamma-lactamase was precipitated, cross-linked and the resulting solid crushed prior to immobilisation within a capillary column microreactor. The microreactor was subsequently used to study enzyme stability, activity, kinetics and substrate specificity... |
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Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.
J. Med. Chem. 52 , 3597-617, (2009)
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Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators.
Bioorg. Med. Chem. Lett. 18 , 5567-70, (2008) Selective androgen receptor modulators (SARMs) are essentially prostate sparing androgens, which provide therapeutic potential in osteoporosis, male hormone replacement, and muscle wasting. Herein we report crystal structures of the androgen receptor (AR) lig... |
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Synthesis of a series of 3-cyanopropionamides and 4-imino-gamma-butyrolactams and evaluation of their function as modulators of multidrug resistance.
Arch. Pharm. (Weinheim) 333(10) , 329-36, (2000) The synthesis of the 3-cyanopropionamides 3a and 3b, of the 2,2-dimethyl-3-cyanopropionamides 4a-4c and of the 4-imino-gamma-butyrolactams 5a and 5b (cyclic functional isomers of 3-cyanopropionamides) is described. The amides 3a and 3b were obtained by aminol... |
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New verapamil related N-homoveratryl propionamides which sensitize tumor cells.
Pharmazie 49(10) , 778-9, (1994)
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Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways.
Mol. Endocrinol. 22(11) , 2448-65, (2008) Androgen receptor (AR) ligands are important for the development and function of several tissues and organs. However, the poor oral bioavailability, pharmacokinetic properties, and receptor cross-reactivity of testosterone, coupled with side effects, place li... |