SPIPERONE N-METHYL- HCL
SPIPERONE N-METHYL- HCL structure
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Common Name | SPIPERONE N-METHYL- HCL | ||
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| CAS Number | 87539-19-3 | Molecular Weight | 409.49600 | |
| Density | 1.25g/cm3 | Boiling Point | 608ºC at 760 mmHg | |
| Molecular Formula | C24H28FN3O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 321.5ºC | |
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Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding.
Synapse 64(9) , 699-703, (2010) In vitro, D(2) dopamine receptors (DAR) can exist in low- and high-affinity states for agonists and increases of D(2) receptors in high-affinity state have been proposed to underlie DA receptor supersensitivity in vivo. Deletion of the gene for dopamine beta-... |
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Frightening music triggers rapid changes in brain monoamine receptors: a pilot PET study.
J. Nucl. Med. 53(10) , 1573-8, (2012) Frightening music can rapidly arouse emotions in listeners that mimic those from actual life-threatening experiences. However, studies of the underlying mechanism for perceiving danger created by music are limited.We investigated monoamine receptor changes in... |
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Competition between 11C-raclopride and endogenous dopamine in Parkinson's disease.
Nucl. Med. Commun. 31(2) , 159-66, (2010) The aim of this study was to understand whether the increase in 11C-raclopride binding in the striatum of patients with Parkinson's disease (PD) is associated with the depletion of endogenous dopamine.Positron emission tomography (PET) scans of the two dopami... |
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A crystallographic and molecular modeling study of butyrophenones.
J. Pharm. Sci. 87(12) , 1496-501, (1998) The X-ray crystal structures of four butyrophenone analogues have been completed and are reported herein. These include spiperone hydrochloride (I), N-methylspiperone hydrochloride (II), pimozide (III), and fluspirilene (IV). These structures were compared to... |
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Effects of endogenous neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in mice.
Biol. Psychiatry 25(5) , 679-89, (2001) Several studies have indicated that the in vivo binding of D(2) receptor positron emission tomography radiotracers can, under some conditions, be influenced by competition with endogenous dopamine. The present study was undertaken to compare the extent to whi... |
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Effects of rolipram on in vivo dopamine receptor binding.
J. Neural Transm. Gen. Sect. 109(9) , 1139-49, (2002) In order to clarify whether changes in brain concentrations of the second messenger cyclic AMP (cAMP) affect in vivo receptor binding in the brain, the effects of rolipram, a selective inhibitor of phosphodiesterase type 4 (PDE(4)), on dopamine receptor bindi... |
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High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.
J. Neurochem. 72(5) , 2127-34, (1999) Many modern models of receptor-G protein function assume that there is a direct relationship between high-affinity agonist binding and efficacy. The validity of this assumption has been recently questioned for the serotonin 5-HT2A receptor. We examined the in... |
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Changes in apparent in vivo binding of [3H]raclopride and [3H]N-methylspiperone induced by oxotremorine.
J. Neural Transm. Gen. Sect. 105(10-12) , 1193-7, (1998) The effects of muscarinic agonist, oxotremorine (0.3 mg/kg), and antagonist, scopolamine (0.5 mg/kg), on in vivo [3H]raclopride (RAC) and [3H]N-methylspiperone (NMSP) binding were investigated. Following tracer administration to control or pretreated mice, bi... |
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Selective alterations of brain dopamine D(2) receptor binding in cirrhotic patients: results of a (11)C-N-methylspiperone PET study.
Metab. Brain Dis. 23(3) , 265-74, (2008) Alterations of the brain dopamine system have been implicated in the neurological complications of chronic liver failure. The present study was aimed at the measurement of dopamine D(2) binding sites in cirrhotic patients by positron emission tomography (PET)... |
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Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments.
Eur. J. Pharmacol. 397(2-3) , 291-6, (2000) An N-terminal dopamine D(2s) receptor clone was constructed and coexpressed in COS-7 cells together with a separate gene fragment coding for the C-terminal sequence of the dopamine D(2s) receptor. The truncated receptor (referred to as D(2trunc)) contained tr... |