Tocopherols
Tocopherols structure
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Common Name | Tocopherols | ||
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| CAS Number | 1406-66-2 | Molecular Weight | 430.70600 | |
| Density | 0.930g/mLat 25°C | Boiling Point | > 200 °C at 1，013 百帕 | |
| Molecular Formula | C29H50O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | > 200 °C - closed cup (lit.) | |
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High-turnover hypoiodite catalysis for asymmetric synthesis of tocopherols.
Science 345(6194) , 291-4, (2014) The diverse biological activities of tocopherols and their analogs have inspired considerable interest in the development of routes for their efficient asymmetric synthesis. Here, we report that chiral ammonium hypoiodite salts catalyze highly chemo- and enan... |
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Metal-free oxidation of aromatic carbon-hydrogen bonds through a reverse-rebound mechanism.
Nature 499(7457) , 192-6, (2013) Methods for carbon-hydrogen (C-H) bond oxidation have a fundamental role in synthetic organic chemistry, providing functionality that is required in the final target molecule or facilitating subsequent chemical transformations. Several approaches to oxidizing... |
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Influence of some packaging materials and of natural tocopherols on the sensory properties of breakfast cereals.
Food Sci. Technol. Int. 20(3) , 161-70, (2014) The combined effect of natural antioxidants and packaging materials on the quality decay of breakfast cereals during storage was evaluated. Corn flakes were produced on industrial scale, using different packages and adding natural tocopherols to the ingredien... |
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First-trimester plasma tocopherols are associated with risk of miscarriage in rural Bangladesh.
Am. J. Clin. Nutr. 101(2) , 294-301, (2015) Tocopherols were discovered for their role in animal reproduction, but little is known about the contribution of deficiencies of vitamin E to human pregnancy loss.We sought to determine whether higher first-trimester concentrations of α-tocopherol and γ-tocop... |
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Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.
Cancer Cell 24(3) , 379-93, (2013) Lysosomal membrane permeabilization and subsequent cell death may prove useful in cancer treatment, provided that cancer cell lysosomes can be specifically targeted. Here, we identify acid sphingomyelinase (ASM) inhibition as a selective means to destabilize ... |
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Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy.
J. Pharmacol. Exp. Ther. 352(1) , 23-32, (2015) Muscular atrophy, a physiopathologic process associated with severe human diseases such as amyotrophic lateral sclerosis (ALS) or cancer, has been linked to reactive oxygen species (ROS) production. The Notch pathway plays a role in muscle development and in ... |
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Treatment of bile acid amidation defects with glycocholic acid.
Hepatology 61(1) , 268-74, (2015) Bile acid amidation defects were predicted to present with fat/fat soluble vitamin malabsorption with minimal cholestasis. We identified and treated five patients (one male, four females) from four families with defective bile acid amidation due to a genetica... |
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Frying stability of high oleic sunflower oils as affected by composition of tocopherol isomers and linoleic acid content.
Food Chem. 141(3) , 2373-8, (2013) The influence of linoleic acid content and tocopherol isomeric composition on the frying performance of high oleic sunflower oil was evaluated during a 14-day restaurant style frying operation. At equal linoleic acid content, no significant difference was obs... |
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Suppression of alpha-tocopherol ether-linked acetic acid in VEGF-induced angiogenesis and the possible mechanisms in human umbilical vein endothelial cells.
Toxicol. Appl. Pharmacol. 281(3) , 310-6, (2014) Alpha-tocopherol ether-linked acetic acid (α-TEA) has been reported to exhibit both anti-tumor and anti-metastatic activities in cell culture and animal studies. However, it is unclear whether α-TEA possesses anti-angiogenic effects. In this study, we investi... |
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Functional modeling identifies paralogous solanesyl-diphosphate synthases that assemble the side chain of plastoquinone-9 in plastids.
J. Biol. Chem. 288(38) , 27594-606, (2013) It is a little known fact that plastoquinone-9, a vital redox cofactor of photosynthesis, doubles as a precursor for the biosynthesis of a vitamin E analog called plastochromanol-8, the physiological significance of which has remained elusive. Gene network re... |