Tubulysin A
Tubulysin A structure
|
Common Name | Tubulysin A | ||
|---|---|---|---|---|
| CAS Number | 205304-86-5 | Molecular Weight | 844.06900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C43H65N5O10S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
|
A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.
Mol. Biol. Cell 26 , 2769-87, (2015) Assembly and sealing of the tight junction barrier are critically dependent on the perijunctional actin cytoskeleton, yet little is known about physical and functional links between barrier-forming proteins and actin. Here we identify a novel functional compl... |
|
|
Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.
Biochem. J. 396 , 235-242, (2006) Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and antiangiogenic agent is explored in the present study. tubA s... |
|
|
An antibody to de-N-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines.
PLoS ONE 6 , e27249, (2011) Polysialic acid (PSA), an α2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its expression is thought to be restricted to a few tissues in adults. Recently, we showed that two human pathogens expressed a derivative ... |