6-Bromo-2H-1,4-benzoxazin-3(4H)-one
6-Bromo-2H-1,4-benzoxazin-3(4H)-one structure
|
Common Name | 6-Bromo-2H-1,4-benzoxazin-3(4H)-one | ||
|---|---|---|---|---|
| CAS Number | 24036-52-0 | Molecular Weight | 228.043 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 376.8±42.0 °C at 760 mmHg | |
| Molecular Formula | C8H6BrNO2 | Melting Point | 220-225ºC | |
| MSDS | USA | Flash Point | 181.7±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.
Bioorg. Med. Chem. 15 , 5912, (2007) We report the design and synthesis of a series of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as orally bioavailable small molecule inhibitors of renin. Compounds with a 2-methyl-2-aryl substitution pattern exhibit potent renin inhibition and good permea... |
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