盐酸多培沙明结构式
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常用名 | 盐酸多培沙明 | 英文名 | Dopexamine hydrochloride |
|---|---|---|---|---|
| CAS号 | 86484-91-5 | 分子量 | 429.42400 | |
| 密度 | N/A | 沸点 | 546.7ºC at 760 mmHg | |
| 分子式 | C22H34Cl2N2O2 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 115.1ºC |
盐酸多培沙明用途Dopexamine hydrochloride 是一种 β2 肾上腺素能受体激动剂。 |
| 中文名 | 盐酸多培沙明 |
|---|---|
| 英文名 | Dopexamine Hydrochloride |
| 中文别名 | 4-[2-[[6-[(2-苯乙基)氨基]己基]氨基]乙基]-1,2-苯二酚二盐酸盐 |
| 英文别名 | 更多 |
| 描述 | Dopexamine hydrochloride 是一种 β2 肾上腺素能受体激动剂。 |
|---|---|
| 相关类别 | |
| 靶点 |
β2 adrenergic receptor[1] |
| 体外研究 | Dopexamine是一种多巴胺类似物,对β2和多巴胺能受体具有激动剂活性。 Dopexamine可以减轻全身炎症反应,减少组织白细胞浸润,并在不改变全球血流动力学或区域微血管流量的剂量下防止器官损伤[1]。 Dopexamine是一种多巴胺类似物,可刺激β-肾上腺素能和多巴胺1和2受体,从而产生一些血管舒张作用。 Dopexamine减少对内毒素的全身炎症反应,包括细胞因子释放,内皮细胞粘附分子和氧化应激,而不会显着改变全身血流动力学,血压或中风量[2]。 |
| 参考文献 |
[2]. Hollenberg SM. Dopexamine: immunomodulatory, hemodynamic, or both? Crit Care. 2013 May 13;17(3):143. |
| 沸点 | 546.7ºC at 760 mmHg |
|---|---|
| 分子式 | C22H34Cl2N2O2 |
| 分子量 | 429.42400 |
| 闪点 | 115.1ºC |
| 精确质量 | 428.20000 |
| PSA | 64.52000 |
| LogP | 6.00840 |
| 储存条件 | 2-8°C |
| 水溶解性 | Soluble in water, sparingly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone. |
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The effect of fenoldopam and dopexamine on cytokine and endotoxin release following on-pump coronary artery bypass grafting: a prospective randomized double-blind trial.
Heart Surg. Forum 13(6) , E353-61, (2010) Surgical trauma, exposure to an external circuit, and reduced organ perfusion contribute to the systemic inflammatory response following cardiopulmonary bypass (CPB). Reduced splanchnic perfusion caus... |
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Is dopexamine superior to dopamine in the treatment of multiple trauma patients—A prospective, double-blind, randomised study
Injury 41(5) , 499-505, (2010) Background The goal of this prospective, randomised, double-blind clinical trial study was to assess the effects of dopexamine hydrochloride on organ failure, inflammatory mediators and splanchnic oxy... |
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Hemodynamic effects of dobutamine and dopexamine after cardiopulmonary bypass in pediatric cardiac surgery.
Paediatr. Anaesth. 19(9) , 862-71, (2009) After surgical repair of congenital heart disease, inotropic support is sometimes necessary to wean from cardiopulmonary bypass. In pediatric cardiac surgery, dobutamine and dopamine are often used as... |
| 4-[2-[6-(2-phenylethylamino)hexylamino]ethyl]benzene-1,2-diol,dihydrochloride |
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