病毒霉素A

• 常用名: 病毒霉素A
• 英文名: Virustomycin A
• CAS号: 84777-85-5
• 分子量: 886.08
• 密度: 1.2±0.1 g/cm3
• 沸点: 989.2±65.0 °C at 760 mmHg
• 分子式: C₄₈H₇₁NO₁₄
• 熔点: N/A
• 闪点: 552.1±34.3 °C

病毒霉素A用途

Virustomycin A是从链霉菌中分离得到的天然产物。Virustomycin A具有选择性和强效抗锥虫体活性[1][2]。

病毒霉素A名称

• 中文名: 病毒霉素A
• 英文名: (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-4-[(3S,4Z,6Z,9R,10S,11S,12R,13R,14Z,16E)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxy-2-pentanyl}-3-O-{(2E)-4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-4-methyl-5-[(1Z)-1-propen-1-yl]-α-D-threo-pentopyranose

病毒霉素A生物活性

• 描述: Virustomycin A是从链霉菌中分离得到的天然产物。Virustomycin A具有选择性和强效抗锥虫体活性[1][2]。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Otoguro K, et, al. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J Antibiot (Tokyo). 2008 Jun;61(6):372-8.

  [2]. Nara A, et, al. Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms. J Antibiot (Tokyo). 2017 May;70(5):616-624.

病毒霉素A物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 989.2±65.0 °C at 760 mmHg
• 分子式: C₄₈H₇₁NO₁₄
• 分子量: 886.08
• 闪点: 552.1±34.3 °C
• 精确质量: 885.487427
• PSA: 231.10000
• LogP: 3.47
• InChIKey: YIKWIQAIKGWYCF-ACOKZJPPSA-N
• SMILES: CC=CC1OC(O)(C(C)C(O)C(C)C2OC(=O)C(OC)=CC(C)=CC(C)C(O)C(CC)C(O)C(C)CC(C)=CC=CC2OC)CC(OC(=O)C=CC(=O)NC2=C(O)CCC2=O)C1C
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.569

病毒霉素A英文别名

• α-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-3-[(3S,4Z,6Z,9R,10S,11S,12R,13R,14Z,16E)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen -2-yl]-2-hydroxy-1-methylbutyl]-3-O-[(2E)-4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-1,4-dioxo-2-buten-1-yl]-4-methyl-5-C-[(1Z)-1-propen-1-yl]-, (5R)-
• (2E)-4-((2-(4-((4Z,6Z,14Z,16E)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)-3-hydroxypentan-2-yl)-2-hydroxy-5-methyl-6-((Z)-prop-1-en-1-yl)tetrahydro-2H-pyran-4-yl)oxy)-N-(2-hydroxy-5-oxocyclopent-1-en-1-yl)-4-oxobut-2-enimidic acid
• (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-4-[(3S,4Z,6Z,9R,10S,11S,12R,13R,14Z,16E)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxy-2-penta ;nyl}-3-O-{(2E)-4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-4-methyl-5-[(1Z)-1-propen-1-yl]-α-D-threo-pentopyranose