吡咯烷四磷酸结构式
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常用名 | 吡咯烷四磷酸 | 英文名 | Pyronaridine tetraphosphate |
|---|---|---|---|---|
| CAS号 | 76748-86-2 | 分子量 | 910.030 | |
| 密度 | 1.357g/cm3 | 沸点 | 657.2ºC at 760 mmHg | |
| 分子式 | C29H44ClN5O18P4 | 熔点 | 233-236° (dec) | |
| MSDS | 中文版 美版 | 闪点 | 351.3ºC | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
吡咯烷四磷酸用途Pyronaridine tetraphosphate 是一种含甘露醇的抗疟疾药物,对耐药的镰状疟原虫,间日疟原虫, 卵形疟原虫和三日疟原虫均具有良好的疗效。 |
| 中文名 | 4-[(7-氯-2-甲氧基-1,5-二氢吡啶并[3,2-b]喹啉-10-基)亚氨]-2,6-二(吡咯烷-1-基甲基)环己-2,5-二烯-1-酮磷酸盐 (1:4) |
|---|---|
| 英文名 | 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoric acid |
| 英文别名 | 更多 |
| 密度 | 1.357g/cm3 |
|---|---|
| 沸点 | 657.2ºC at 760 mmHg |
| 熔点 | 233-236° (dec) |
| 分子式 | C29H44ClN5O18P4 |
| 分子量 | 910.030 |
| 闪点 | 351.3ºC |
| 精确质量 | 909.132019 |
| PSA | 424.03000 |
| LogP | 2.32020 |
| 折射率 | 1.72 |
| 储存条件 | 2-8°C |
| 水溶解性 | acetic acid: soluble5mg/mL |
| 符号 |
GHS07, GHS08 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302-H361 |
| 警示性声明 | P280-P301 + P312 + P330 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| 危害码 (欧洲) | Xn |
| 风险声明 (欧洲) | 63-22-41 |
| 安全声明 (欧洲) | 26-36/37-39 |
| 危险品运输编码 | NONH for all modes of transport |
| RTECS号 | SK4920000 |
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JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium.
Antimicrob. Agents Chemother. 59(1) , 170-7, (2014) 4-(tert-Butyl)-2-((tert-butylamino)methyl)-6-(6-(trifluoromethyl)pyridin-3-yl)-phenol (JPC-2997) is a new aminomethylphenol compound that is highly active in vitro against the chloroquine-sensitive D6... |
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In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs.
Antimicrob. Agents Chemother. 50 , 2883-2885, (2006) In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interac... |
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In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon.
Antimicrob. Agents Chemother. 47 , 1391-1394, (2003) The spread of chloroquine-resistant Plasmodium falciparum calls for a constant search for new drugs. The in vitro activity of piperaquine, a new Chinese synthetic drug belonging to the bisquinolines, ... |
| Pyronaridine phosphate |
| Phenol,4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)-,phosphate (1:4) |
| Pyronaridine Tetraphosphate |
| UNII-2T289F9ACO |
| 4-[(7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol phosphate (1:4) |
| Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-, phosphate (1:4) (salt) |
| Pyranoridine phosphate |
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