Pyronaridine tetraphosphate
Modify Date: 2025-08-25 19:52:46
Pyronaridine tetraphosphate structure
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Common Name | Pyronaridine tetraphosphate | ||
|---|---|---|---|---|
| CAS Number | 76748-86-2 | Molecular Weight | 910.030 | |
| Density | 1.357g/cm3 | Boiling Point | 657.2ºC at 760 mmHg | |
| Molecular Formula | C29H44ClN5O18P4 | Melting Point | 233-236° (dec) | |
| MSDS | Chinese USA | Flash Point | 351.3ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
Use of Pyronaridine tetraphosphatePyronaridine tetraphosphate is a Mannich base anti-malarial with demonstrated efficacy against drug resistant Plasmodium falciparum, P. vivax, P. ovale and P. malariae. |
| Name | 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoric acid |
|---|---|
| Synonym | More Synonyms |
| Description | Pyronaridine tetraphosphate is a Mannich base anti-malarial with demonstrated efficacy against drug resistant Plasmodium falciparum, P. vivax, P. ovale and P. malariae. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.357g/cm3 |
|---|---|
| Boiling Point | 657.2ºC at 760 mmHg |
| Melting Point | 233-236° (dec) |
| Molecular Formula | C29H44ClN5O18P4 |
| Molecular Weight | 910.030 |
| Flash Point | 351.3ºC |
| Exact Mass | 909.132019 |
| PSA | 424.03000 |
| LogP | 2.32020 |
| Index of Refraction | 1.72 |
| Storage condition | 2-8°C |
| Water Solubility | acetic acid: soluble5mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H361 |
| Precautionary Statements | P280-P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 63-22-41 |
| Safety Phrases | 26-36/37-39 |
| RIDADR | NONH for all modes of transport |
| RTECS | SK4920000 |
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JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium.
Antimicrob. Agents Chemother. 59(1) , 170-7, (2014) 4-(tert-Butyl)-2-((tert-butylamino)methyl)-6-(6-(trifluoromethyl)pyridin-3-yl)-phenol (JPC-2997) is a new aminomethylphenol compound that is highly active in vitro against the chloroquine-sensitive D6... |
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In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs.
Antimicrob. Agents Chemother. 50 , 2883-2885, (2006) In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interac... |
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In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon.
Antimicrob. Agents Chemother. 47 , 1391-1394, (2003) The spread of chloroquine-resistant Plasmodium falciparum calls for a constant search for new drugs. The in vitro activity of piperaquine, a new Chinese synthetic drug belonging to the bisquinolines, ... |
| Pyronaridine phosphate |
| Phenol,4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)-,phosphate (1:4) |
| Pyronaridine Tetraphosphate |
| UNII-2T289F9ACO |
| 4-[(7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol phosphate (1:4) |
| Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-, phosphate (1:4) (salt) |
| Pyranoridine phosphate |