76748-86-2

• 常用中文名：吡咯烷四磷酸
• 常用英文名：Pyronaridine tetraphosphate
• CAS号：76748-86-2
• 分子式：C₂₉H₄₄ClN₅O₁₈P₄
• 分子量：910.030
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 二氢吡啶
• 发布时间：2019-01-01 19:38:22
• 更新时间：2024-01-02 18:57:05
• Pyronaridine tetraphosphate 是一种含甘露醇的抗疟疾药物,对耐药的镰状疟原虫,间日疟原虫, 卵形疟原虫和三日疟原虫均具有良好的疗效。

名称

• 中文名: 4-[(7-氯-2-甲氧基-1,5-二氢吡啶并[3,2-b]喹啉-10-基)亚氨]-2,6-二(吡咯烷-1-基甲基)环己-2,5-二烯-1-酮磷酸盐 (1:4)
• 英文名: 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoric acid
• 英文别名: Pyronaridine phosphate; Phenol,4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)-,phosphate (1:4); Pyronaridine Tetraphosphate; UNII-2T289F9ACO; 4-[(7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol phosphate (1:4); Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-, phosphate (1:4) (salt); Pyranoridine phosphate

物化性质

• 密度: 1.357g/cm3
• 沸点: 657.2ºC at 760 mmHg
• 熔点: 233-236° (dec)
• 分子式: C₂₉H₄₄ClN₅O₁₈P₄
• 分子量: 910.030
• 闪点: 351.3ºC
• 精确质量: 909.132019
• PSA: 424.03000
• LogP: 2.32020
• 折射率: 1.72
• 储存条件: 2-8°C
• 水溶解性: acetic acid: soluble5mg/mL

生物活性

• 描述: Pyronaridine tetraphosphate 是一种含甘露醇的抗疟疾药物,对耐药的镰状疟原虫,间日疟原虫, 卵形疟原虫和三日疟原虫均具有良好的疗效。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 感染
• 参考文献:

  [1]. Vivas L, et al. Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta Trop. 2008 Mar;105(3):222-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SK4920000 CAS REGISTRY NUMBER : 76748-86-2 LAST UPDATED : 199509 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C29-H32-Cl-N5-O2.4H3-O4-P MOLECULAR WEIGHT : 910.11 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1368 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 251 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2800 mg/kg/14D-I TOXIC EFFECTS : Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2320 mg/kg SEX/DURATION : male 9 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1100 mg/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 990 mg/kg SEX/DURATION : female 7-9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 252 mg/kg SEX/DURATION : female 7-9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 ug/plate REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 3,51,1982

安全

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H302-H361
• 警示性声明: P280-P301 + P312 + P330
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 63-22-41
• 安全声明 (欧洲): 26-36/37-39
• 危险品运输编码: NONH for all modes of transport
• RTECS号: SK4920000