PPACKII (trifluoroacetate salt)

• 常用名: PPACKII (trifluoroacetate salt)
• 英文名: PPACKII (trifluoroacetate salt)
• CAS号: 649748-23-2
• 分子量: 729.068
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₅ClF₆N₆O₇
• 熔点: N/A
• 闪点: N/A

PPACKII (trifluoroacetate salt)用途

PPACK II diTFA是一种不可逆的特异性腺体和血浆激肽释放酶抑制剂[1]。

PPACKII (trifluoroacetate salt)名称

• 英文名: D-Phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxo-3-hexanyl]-L-phenylalaninamide trifluoroacetate (1:2)

PPACKII (trifluoroacetate salt)生物活性

• 描述: PPACK II diTFA是一种不可逆的特异性腺体和血浆激肽释放酶抑制剂[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> Ser/Thr蛋白酶
  研究领域 >> 心血管疾病
• 体外研究: PPACK II(0.62-50μg/mL)双TFA显着抑制 B型钠尿肽 (BNP)蛋白水解[2]。
• 参考文献:

  [1]. Kentaro Takayama, et al. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers. 2016 Nov 4;106(4):440-5.

  [2]. Alexander Belenky, et al. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clin Chim Acta. 2004 Feb;340(1-2):163-72.

PPACKII (trifluoroacetate salt)物理化学性质

• 分子式: C₂₉H₃₅ClF₆N₆O₇
• 分子量: 729.068
• 精确质量: 728.216003
• InChIKey: JVMDQRDDGVKUMG-WOSURGFKSA-N
• SMILES: NC(N)=NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(N)Cc1ccccc1)C(=O)CCl.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

PPACKII (trifluoroacetate salt)英文别名

• Acetic acid, 2,2,2-trifluoro-, compd. with L-phenylalaninamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]- (2:1)
• D-Phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxo-3-hexanyl]-L-phenylalaninamide trifluoroacetate (1:2)