PPACKII (trifluoroacetate salt)

Modify Date: 2025-08-25 18:29:40

PPACKII (trifluoroacetate salt) structure	Common Name	PPACKII (trifluoroacetate salt)
	CAS Number	649748-23-2	Molecular Weight	729.068
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₃₅ClF₆N₆O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PPACKII (trifluoroacetate salt)

PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor[1].

Name	D-Phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxo-3-hexanyl]-L-phenylalaninamide trifluoroacetate (1:2)
Synonym	More Synonyms

Description	PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cardiovascular Disease
In Vitro	PPACK II (0.62-50 μg/mL) diTFA 显着抑制 B 型钠尿肽 (BNP) 蛋白水解[2]。
References	[1]. Kentaro Takayama, et al. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers. 2016 Nov 4;106(4):440-5. [2]. Alexander Belenky, et al. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clin Chim Acta. 2004 Feb;340(1-2):163-72.

Molecular Formula	C₂₉H₃₅ClF₆N₆O₇
Molecular Weight	729.068
Exact Mass	728.216003
InChIKey	JVMDQRDDGVKUMG-WOSURGFKSA-N
SMILES	NC(N)=NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(N)Cc1ccccc1)C(=O)CCl.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Acetic acid, 2,2,2-trifluoro-, compd. with L-phenylalaninamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]- (2:1)

D-Phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxo-3-hexanyl]-L-phenylalaninamide trifluoroacetate (1:2)

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Price: ￥1800/5 mg