649748-23-2

649748-23-2 structure

Name: PPACKII (trifluoroacetate salt)
Chemical Name: D-Phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxo-3-hexanyl]-L-phenylalaninamide trifluoroacetate (1:2)
CAS Number: 649748-23-2
Molecular Formula: C₂₉H₃₅ClF₆N₆O₇
Molecular Weight: 729.068
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2018-06-03 22:52:05
Modify Date: 2024-02-09 12:57:29
PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor[1].

Name	D-Phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxo-3-hexanyl]-L-phenylalaninamide trifluoroacetate (1:2)
Synonyms	Acetic acid, 2,2,2-trifluoro-, compd. with L-phenylalaninamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]- (2:1) D-Phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxo-3-hexanyl]-L-phenylalaninamide trifluoroacetate (1:2)

Description	PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cardiovascular Disease
In Vitro	PPACK II (0.62-50 μg/mL) diTFA 显着抑制 B 型钠尿肽 (BNP) 蛋白水解[2]。
References	[1]. Kentaro Takayama, et al. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers. 2016 Nov 4;106(4):440-5. [2]. Alexander Belenky, et al. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clin Chim Acta. 2004 Feb;340(1-2):163-72.