PPACKII (trifluoroacetate salt)

Names

[ Name ]:
PPACKII (trifluoroacetate salt)

[Synonym ]:
Acetic acid, 2,2,2-trifluoro-, compd. with L-phenylalaninamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]- (2:1)
D-Phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxo-3-hexanyl]-L-phenylalaninamide trifluoroacetate (1:2)

Biological Activity

[Description]:

PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Cardiovascular Disease

[In Vitro]

PPACK II (0.62-50 μg/mL) diTFA 显着抑制 B 型钠尿肽 (BNP) 蛋白水解[2]。

[References]

[1]. Kentaro Takayama, et al. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers. 2016 Nov 4;106(4):440-5.

[2]. Alexander Belenky, et al. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clin Chim Acta. 2004 Feb;340(1-2):163-72.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₅ClF₆N₆O₇

[ Molecular Weight ]:
729.068

[ Exact Mass ]:
728.216003

Related Compounds

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