盐酸曲普利啶

更新时间：2025-08-25 13:31:34

盐酸曲普利啶结构式	常用名	盐酸曲普利啶	英文名	Triprolidine hydrochloride
	CAS号	6138-79-0	分子量	314.85200
	密度	N/A	沸点	462ºC at 760 mmHg
	分子式	C₁₉H₂₅ClN₂O	熔点	115-120ºC
	MSDS	中文版美版	闪点	233.2ºC
	符号	GHS07	信号词	Warning

盐酸曲普利啶用途

盐酸曲普利啶是一种口服活性、细胞渗透性和第一代组胺H1拮抗剂[1]。盐酸曲普利啶是一种抗组胺药,可用于过敏性鼻炎、哮喘和荨麻疹[2]。

中文名	盐酸曲普利啶
英文名	triprolidine hydrochloride monohydrate
英文别名	更多

描述	盐酸曲普利啶是一种口服活性、细胞渗透性和第一代组胺H1拮抗剂[1]。盐酸曲普利啶是一种抗组胺药,可用于过敏性鼻炎、哮喘和荨麻疹[2]。
相关类别	信号通路 >> 免疫及炎症 >> 组胺受体研究领域 >> 神经疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
靶点	H1 Receptor
体内研究	曲普利啶(间隔内注射；0.5μl中0.5μM；破伤风后30、60和180 min)对基线fEPSPs没有显著影响,但是,与盐水注射(60 min时为208%)相比,步行时诱导的长时程增强(LTP)较小(60 min时为基线值的173%)[2]。动物模型：成年雄性Long-Evans TMN(tuberomamillary nucleus,TMN)损伤大鼠[2]剂量：0.5μl给药0.5μm：间隔内灌注；破伤风后30、60、180min结果：LTP的步行相关增强减弱。
参考文献	[1]. Tao Luo, et al. Endogenous Histamine Facilitates Long-Term Potentiation in the Hippocampus During WalkingJ Neurosci. 2010 Jun 9;30(23):7845-52. [2]. Sang-Chul Shin, et al. Controlled Release of Triprolidine Using Ethylene-Vinyl Acetate Membrane and Matrix Systems. Eur J Pharm Biopharm

沸点	462ºC at 760 mmHg
熔点	115-120ºC
分子式	C₁₉H₂₅ClN₂O
分子量	314.85200
闪点	233.2ºC
精确质量	314.15500
PSA	16.13000
LogP	4.65740
InChIKey	WYUYEJNGHIOFOC-NWBUNABESA-N
SMILES	Cc1ccc(C(=CCN2CCCC2)c2ccccn2)cc1.Cl
外观性状	白色结晶粉末
储存条件	2-8°C
稳定性	Stable, but discolours in light. Incompatible with strong oxidizing agents.
水溶解性	>=10 g/100 mL at 20 ºC

盐酸曲普利啶MSDS英文版

盐酸曲普利啶毒性英文版

符号	GHS07
信号词	Warning
危害声明	H302-H315-H319-H335
警示性声明	P301 + P312 + P330-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xn:Harmful;
风险声明 (欧洲)	R22;R36/37/38
安全声明 (欧洲)	S26-S36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	UT7658000

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J. Neurophysiol. 113 , 3720-35, (2015)

Histamine receptors are densely expressed in the mesencephalic trigeminal nucleus (MesV) and trigeminal motor nucleus. However, little is known about the functional roles of neuronal histamine in cont...

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The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The l...

Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography.

J. Pharm. Biomed. Anal. 43(1) , 293-7, (2007)

An automated solid-phase extraction method was developed for the determination of the H1-antihistamine acrivastine in plasma samples. Acrivastine was analyzed at the wavelength of 254 nm using a rever...

MFCD00150574

Triprolidine hydrochloride