Notomycin A1结构式
|
常用名 | Notomycin A1 | 英文名 | COUMERMYCIN AL |
|---|---|---|---|---|
| CAS号 | 4434-05-3 | 分子量 | 1110.08000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C55H59N5O20 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
Notomycin A1用途Coumermycin A1 是一种 JAK2 信号激活剂。Coumermycin A1 抑制 DNA 旋转酶 (b>DNA Gyrase),从而抑制细菌的细胞分裂。 |
| 中文名 | 香豆霉素 |
|---|---|
| 英文名 | coumermycin A1 |
| 中文别名 | 脊霉素 | 香豆毒素A1 |
| 英文别名 | 更多 |
| 描述 | Coumermycin A1 是一种 JAK2 信号激活剂。Coumermycin A1 抑制 DNA 旋转酶 (b>DNA Gyrase),从而抑制细菌的细胞分裂。 |
|---|---|
| 相关类别 | |
| 体外研究 | 古霉素A1诱导的JAK2信号激活增加了SCOS2的mRNA水平,但降低了瘦素受体的mRNA水平[1]。 |
| 参考文献 |
| 分子式 | C55H59N5O20 |
|---|---|
| 分子量 | 1110.08000 |
| 精确质量 | 1109.38000 |
| PSA | 354.89000 |
| LogP | 5.71790 |
| 外观性状 | 固体 |
| 储存条件 | 2-8°C，密封，干燥 |
| Notomycin A1上游产品 9 | |
|---|---|
| Notomycin A1下游产品 0 | |
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Multiplexing interactions to control antibiotic release from cyclodextrin hydrogels.
Macromol. Biosci. 11(11) , 1544-52, (2011) A new strategy for affinity-based drug delivery by modification of the drug rather than modification of the device is presented. Rifampin is modified to contain either one or two PEG-adamantane arms, ... |
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Aminocoumarins inhibit osteoclast differentiation and bone resorption via downregulation of nuclear factor of activated T cells c1.
Biochem. Pharmacol. 85(3) , 417-25, (2013) Aminocoumarins, such as coumermycin A1 and novobiocin, are natural products of streptomycetes. They are potent inhibitors of bacterial DNA gyrase and are used to suppress the growth of bacteria in inf... |
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Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization.
J. Biol. Chem. 281 , 7161-7171, (2006) The C-terminal domain of Hsp90 displays independent chaperone activity, mediates dimerization, and contains the MEEVD motif essential for interaction with tetratricopeptide repeat-containing immunophi... |
| coumamycin |
| l)oxy)-4-hydroxy-8-methylcoumarin) |
| Sugordomycin D-la |
| Coumermycin |
| Cumamycin |
| coumermycins |
| notomycina1 |
| COUMERMYCIN A1 |
| Notomycin |
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