4434-05-3

• 常用中文名：Notomycin A1
• 常用英文名：COUMERMYCIN AL
• CAS号：4434-05-3
• 分子式：C₅₅H₅₉N₅O₂₀
• 分子量：1110.08000
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-02-09 08:00:00
• 更新时间：2025-08-21 11:43:02
• Coumermycin A1 是一种 JAK2 信号激活剂。Coumermycin A1 抑制 DNA 旋转酶 (b>DNA Gyrase),从而抑制细菌的细胞分裂。

名称

• 中文名: 香豆霉素
• 英文名: coumermycin A1
• 中文别名: 脊霉素; 香豆毒素A1
• 英文别名: coumamycin; l)oxy)-4-hydroxy-8-methylcoumarin); Sugordomycin D-la; Coumermycin; Cumamycin; coumermycins; notomycina1; COUMERMYCIN A1; Notomycin

物化性质

• 分子式: C₅₅H₅₉N₅O₂₀
• 分子量: 1110.08000
• 精确质量: 1109.38000
• PSA: 354.89000
• LogP: 5.71790
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Coumermycin A1 是一种 JAK2 信号激活剂。Coumermycin A1 抑制 DNA 旋转酶 (b>DNA Gyrase),从而抑制细菌的细胞分裂。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 古霉素A1诱导的JAK2信号激活增加了SCOS2的mRNA水平,但降低了瘦素受体的mRNA水平[1]。
• 参考文献:

  [1]. Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Research Article.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UX9375000 CHEMICAL NAME : Pyrrole-2-carboxylic acid, 5-methyl-, diester with 3,3'-((3-methylpyrrole-2,4-diyl) bis(carbonylimino))bis(7-((5,5-di-C-methyl-4-O-methyl -alpha-L-lyxopyranosy l)oxy)-4-hydroxy -8-methylcoumarin) CAS REGISTRY NUMBER : 4434-05-3 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C55-H59-N5-O20 MOLECULAR WEIGHT : 1110.19 WISWESSER LINE NOTATION : T66 BOVJ EQ J1 IO- FT6OTJ B1 B1 CO1 EQ DOV- BT5MJ E1&& DMV- DT5M BUTJ C1 BVM- DT66 BOVJ EQ J1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 159 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 200 mg/L REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 271,385,1978

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 22
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• RTECS号: UX9375000

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