COUMERMYCIN AL

Modify Date: 2024-01-09 12:17:47

COUMERMYCIN AL structure	Common Name	COUMERMYCIN AL
	CAS Number	4434-05-3	Molecular Weight	1110.08000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₅H₅₉N₅O₂₀	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of COUMERMYCIN AL

Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.

Name	coumermycin A1
Synonym	More Synonyms

Description	Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Coumermycin A1-induced-JAK2 signal activation increases the mRNA level of SCOS2, but reducea leptin receptor mRNA level[1].
References	[1]. Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Research Article.

Molecular Formula	C₅₅H₅₉N₅O₂₀
Molecular Weight	1110.08000
Exact Mass	1109.38000
PSA	354.89000
LogP	5.71790

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9375000

CHEMICAL NAME :: Pyrrole-2-carboxylic acid, 5-methyl-, diester with 3,3'-((3-methylpyrrole-2,4-diyl) bis(carbonylimino))bis(7-((5,5-di-C-methyl-4-O-methyl -alpha-L-lyxopyranosy l)oxy)-4-hydroxy -8-methylcoumarin)

CAS REGISTRY NUMBER :: 4434-05-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C55-H59-N5-O20

MOLECULAR WEIGHT :: 1110.19

WISWESSER LINE NOTATION :: T66 BOVJ EQ J1 IO- FT6OTJ B1 B1 CO1 EQ DOV- BT5MJ E1&& DMV- DT5M BUTJ C1 BVM- DT66 BOVJ EQ J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 159 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 200 mg/L

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 271,385,1978

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	22
Safety Phrases	36
RIDADR	NONH for all modes of transport
RTECS	UX9375000

Precursor 9
CAS#:3780-41-4 3-Methyl-1H-pyr... CAS#:3757-53-7 5-Methyl-1H-pyr... CAS#:3284-51-3 Ethyl 5-methyl-... CAS#:303-81-1 Novobiocin
CAS#:3780-28-7 3-(5-methyl-1H-... CAS#:245729-77-5 (3R,4S,5R,6R)-6... CAS#:251354-68-4 5-methyl-1H-pyr... CAS#:374749-50-5 noviose 1,2-ace...
CAS#:374749-49-2 (3aR,6R,7R,7aR)...
DownStream 0

Multiplexing interactions to control antibiotic release from cyclodextrin hydrogels.

Macromol. Biosci. 11(11) , 1544-52, (2011)

A new strategy for affinity-based drug delivery by modification of the drug rather than modification of the device is presented. Rifampin is modified to contain either one or two PEG-adamantane arms, ...

Aminocoumarins inhibit osteoclast differentiation and bone resorption via downregulation of nuclear factor of activated T cells c1.

Biochem. Pharmacol. 85(3) , 417-25, (2013)

Aminocoumarins, such as coumermycin A1 and novobiocin, are natural products of streptomycetes. They are potent inhibitors of bacterial DNA gyrase and are used to suppress the growth of bacteria in inf...

Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization.

J. Biol. Chem. 281 , 7161-7171, (2006)

The C-terminal domain of Hsp90 displays independent chaperone activity, mediates dimerization, and contains the MEEVD motif essential for interaction with tetratricopeptide repeat-containing immunophi...

coumamycin

l)oxy)-4-hydroxy-8-methylcoumarin)

Sugordomycin D-la

Coumermycin

Cumamycin

coumermycins

notomycina1

COUMERMYCIN A1

Notomycin

DC Chemicals Limited
China
Product Name: Coumermycin A1
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: COUMERMYCIN AL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Use of COUMERMYCIN AL

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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Synonyms