盐酸西维美林

• 常用名: 盐酸西维美林
• 英文名: Cevimeline hydrochloride hemihydrate
• CAS号: 153504-70-2
• 分子量: 435.09
• 密度: 1.19g/cm3
• 沸点: 308.5ºC at 760mmHg
• 分子式: C₂₀H₃₅ClN₂O₂S₂
• 熔点: N/A
• 闪点: 140.4ºC
• 符号: GHS06
• 信号词: Danger

盐酸西维美林用途

Cevimeline盐酸半水合物是毒蕈碱型受体激动剂。

盐酸西维美林名称

• 中文名: 盐酸西维美林
• 英文名: Cevimelinehydrochloride
• 中文别名: (+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物 | 西维美林盐酸盐半水合物

盐酸西维美林生物活性

• 描述: Cevimeline盐酸半水合物是毒蕈碱型受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Iga Y, Arisawa H, Ogane N, Saito Y, Tomizuka T, Nakagawa-Yagi Y, Masunaga H, Yasuda H, Miyata N. (+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate (SNI-2011, cevimeline hydrochloride) induces saliva and tear secretions

  [2]. Omori Y, Asari T, Maruyama K, Kusama H, Kojima M, Shibata N. Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation. Arzneimittelforschung. 2003;53(5):342-50.

  [3]. Washio, Takuo; Kohsaka, Kazuhiro; Arisawa, Hirohiko; et al.Pharmacokinetics and metabolism of radiolabeled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers: Comprehensive understanding of absorption, metabolism and excretion using radi

  [4]. Washio, Takuo; Kohsaka, Kazuhiro; Arisawa, Hirohiko; et al.Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs.Arzneimittel-Forschung (2003), 53(1), 26-33.

  [5]. Arisawa, Hirohiko; Fukui, Kenji; Imai, Eiichi; et al.General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjogren's syndrome. Arzneimittel-Forschung (2002), 52(4), 225-232.

盐酸西维美林物理化学性质

• 密度: 1.19g/cm3
• 沸点: 308.5ºC at 760mmHg
• 分子式: C₂₀H₃₅ClN₂O₂S₂
• 分子量: 435.09
• 闪点: 140.4ºC
• PSA: 84.77000
• LogP: 4.53590
• 外观性状: 固体
• 蒸汽压: 0.000676mmHg at 25°C
• 储存条件: -20°C

盐酸西维美林MSDS

盐酸西维美林MSDS英文版

盐酸西维美林毒性和生态

盐酸西维美林安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: P301 + P310
• 危险品运输编码: UN 2811 6.1 / PGIII

盐酸西维美林英文别名

• Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, (3R)-, hydrochloride, hydrate (2:2:1)
• cis-2-Methylspiro(1,3-oxathiolane-5,3')quinuclidine hydrochloride hydrate (2:2:1)
• Unii-p81Q6V85np
• (+/-)-cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride hemihydrate
• cevimeline hydrochloride
• (2R,2'R)-2'-Methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane] hydrochloride hydrate (2:2:1)
• CeviMeline hydrochloride heMihydrates
• Cevimeline hydrochloride hemihydrate
• (2R)-2'-Methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane] hydrochloride hydrate (2:2:1)
• Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, (2'R,3R)-, hydrochloride, hydrate (2:2:1)
• (+/-)-cis-2-methylspiro[1,2-oxathiolane-5,3'-quinclidine] monohydrochloride
• Cevimeline HCl 1/2H2o
• (+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] monohydrochloride
• (+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine]monohydrochloride hemihydrate
• CevimelineHCl
• Cevimeline (hydrochloride hemihydrate)