醋酸西曲瑞克

更新时间:2024-01-03 12:50:04

醋酸西曲瑞克结构式
醋酸西曲瑞克结构式
品牌特惠专场
常用名 醋酸西曲瑞克 英文名 Cetrorelix Acetate
CAS号 145672-81-7 分子量 1491.09000
密度 N/A 沸点 N/A
分子式 C72H96ClN17O16 熔点 N/A
MSDS 中文版 美版 闪点 N/A
符号 GHS08
GHS08
信号词 Warning

 醋酸西曲瑞克用途


Cetrorelix Acetate是 GnRH 受体的强效拮抗剂,其 IC50 值为 1.21 nM.

 醋酸西曲瑞克名称

中文名 醋酸西曲瑞克
英文名 cetrorelix acetate

 醋酸西曲瑞克生物活性

描述 Cetrorelix Acetate是 GnRH 受体的强效拮抗剂,其 IC50 值为 1.21 nM.
相关类别
靶点

IC50: 1.21 nM GnRH[1].

体外研究 Cetrorelix Acetate以1000ng/ml抑制ES-2细胞系的生长。 Cetrorelix Acetate具有与GnRH-I激动剂相当的抗增殖作用,表明GnRH-I激动剂和拮抗剂的二分法可能不适用于癌细胞中的GnRH-I系统[2]。
参考文献

[1]. Beckers T et al. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal Biochem. 1997 Aug 15;251(1):17-23.

[2]. Gründker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65.

 醋酸西曲瑞克物理化学性质

分子式 C72H96ClN17O16
分子量 1491.09000
精确质量 1489.69000
PSA 532.97000
LogP 6.02320
储存条件 -20°C

 醋酸西曲瑞克安全信息

符号 GHS08
GHS08
信号词 Warning
危害声明 H361
警示性声明 P281
危险品运输编码 NONH for all modes of transport

 醋酸西曲瑞克文献20

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