西曲瑞克

更新时间：2024-01-02 18:06:42

西曲瑞克结构式	常用名	西曲瑞克	英文名	Antide acetate salt
	CAS号	120287-85-6	分子量	1431.038
	密度	1.4±0.1 g/cm3	沸点	N/A
	分子式	C₇₀H₉₂ClN₁₇O₁₄	熔点	N/A
	MSDS	N/A	闪点	N/A

西曲瑞克用途

西曲利是一种有效的促性腺激素释放激素(GnRH)拮抗剂。西曲利抑制卵巢刺激期间内源性黄体生成激素激增。西替罗利减少环磷酰胺诱导的小鼠卵巢卵泡破坏[1][2]。

中文名	醋酸西曲瑞克
英文名	cetrorelix
中文别名	醋酸西曲瑞克 CETRORELIXACETATE
英文别名	更多

描述	西曲利是一种有效的促性腺激素释放激素(GnRH)拮抗剂。西曲利抑制卵巢刺激期间内源性黄体生成激素激增。西替罗利减少环磷酰胺诱导的小鼠卵巢卵泡破坏[1][2]。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> GNRH受体研究领域 >> 内分泌
参考文献	[1]. Diedrich K, et al. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod. 1994 May;9(5):788-91. [2]. Meirow D, et al. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice. Hum Reprod. 2004 Jun;19(6):1294-9.

描述

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> GNRH受体

研究领域 >> 内分泌

参考文献

[1]. Diedrich K, et al. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod. 1994 May;9(5):788-91.

[2]. Meirow D, et al. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice. Hum Reprod. 2004 Jun;19(6):1294-9.

密度	1.4±0.1 g/cm3
分子式	C₇₀H₉₂ClN₁₇O₁₄
分子量	1431.038
精确质量	1429.669800
PSA	495.67000
LogP	2.69
外观性状	白色粉末
折射率	1.668
储存条件	2-8°C

BOC-L-脯氨酸

15761-39-4

BOC-L-亮氨酸

13139-15-6

BOC-DL-丙氨酸

3744-87-4

叔丁氧羰基-甲苯磺酰基-精氨酸

13836-37-8

详细

文献：Journal of medicinal chemistry, , vol. 36, # 7 p. 928 - 933

西曲瑞克上游产品 4
CAS号15761-39-4 BOC-L-脯氨酸 CAS号13139-15-6 BOC-L-亮氨酸 CAS号3744-87-4 BOC-DL-丙氨酸 CAS号13836-37-8 叔丁氧羰基-甲苯磺酰基-精氨酸
西曲瑞克下游产品 0

N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide

CETRORELIX ACETATE(CETROTIDE)

N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2

Cetrorelixum [inn-latin]

(2S)-N-[(2R)-1-Amino-1-oxopropan-2-yl]-1-[(2S,5S,8R,11S,14S,17R,20R,23R)-2-(3-carbamimidamidopropyl)-8-[3-(carbamoylamino)propyl]-20-(4-chlorobenzyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-23-(2-naphthylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(pyridin-3-ylmethyl)-3,6,9,12,15,18,21,24-octaazahexacosan-1-oyl]pyrrolidine-2-carboxamide (non-preferred name)

Ac-DNal-DpCl-Phe-DPal-Ser-Tyr-DCit-Leu-Arg-Pro-D-Ala-NH2

N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide

Cetrorelixacetate

Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2

AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH

Cetrorelixum

cetrorelixum [INN_la]

CETRORELIX ACID

D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-

Unii-oon1hfz4ba

CETRIZINEDIHYDROCHLORIDE

Cetrorelix acetate

N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-L-tyrosyl-N-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide

AC-D-2-NAL-4-CHLORO-D-PHE-B-(3-PYRIDYL)-D-ALA-SER-TYR-D-CIT-LEU-ARG-PRO-D-ALA-NH2

Cetrorelix