ARQ092盐酸盐

• 常用名: ARQ092盐酸盐
• 英文名: Miransertib HCl
• CAS号: 1313883-00-9
• 分子量: 468.981
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₅ClN₆
• 熔点: N/A
• 闪点: N/A

ARQ092盐酸盐用途

Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. ARQ-092 demonstrated high enzymatic potency against AKT1, AKT2, and AKT3, as well as potent cellular inhibition of AKT activation and the phosphorylation of the downstream target PRAS40. ARQ-092 also served as a potent inhibitor of the AKT1-E17K mutant protein and inhibited tumor growth in a human xenograft mouse model of endometrial adenocarcinoma.

ARQ092盐酸盐名称

• 中文名: ARQ092盐酸盐
• 英文名: 3-{3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl}-2-pyridinamine hydrochloride (1:1)

ARQ092盐酸盐物理化学性质

• 分子式: C₂₇H₂₅ClN₆
• 分子量: 468.981
• 精确质量: 468.182922
• 外观性状: 粉末
• 储存条件: -20℃

ARQ092盐酸盐英文别名

• 3-{3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl}-2-pyridinamine hydrochloride (1:1)
• MFCD31536778
• 2-Pyridinamine, 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-, hydrochloride (1:1)