GW791343(盐酸盐)

• 常用名: GW791343(盐酸盐)
• 英文名: GW791343
• CAS号: 1019779-04-4
• 分子量: 447.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₆Cl₂F₂N₄O
• 熔点: N/A
• 闪点: N/A

GW791343(盐酸盐)用途

GW791343双盐酸盐是P2X7变构调节剂,有种属特异性,对人P2X7的pIC50为6.9-7.2。

GW791343(盐酸盐)名称

• 中文名: GW791343(盐酸盐)
• 英文名: GW 791343 hydrochloride,2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamidetrihydrochloride
• 中文别名: 2-[(3,4-二氟苯基)氨基]-N-[2-甲基-5-(1-哌嗪基甲基)苯基]乙酰胺盐酸盐

GW791343(盐酸盐)生物活性

• 描述: GW791343双盐酸盐是P2X7变构调节剂,有种属特异性,对人P2X7的pIC50为6.9-7.2。
• 相关类别:
  信号通路 >> 跨膜转运 >> P2X受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Michel AD, et al. Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects. Br J Pharmacol, 2008, 155(5), 738-751.

  [2]. Felix RA, et al. Development of a comprehensive set of P2 receptor pharmacological research compounds. Purinergic Signal, 2012, 8(Suppl 1), 101-112.

  [3]. Roman S, et al. Cloning and pharmacological characterization of the dog P2X7 receptor. Br J Pharmacol, 2009, 158(6), 1513-1526.

  [4]. Michel AD, et al. Negative and positive allosteric modulators of the P2X(7) receptor. Br J Pharmacol, 2008, 153(4), 737-750.

GW791343(盐酸盐)物理化学性质

• 分子式: C₂₀H₂₆Cl₂F₂N₄O
• 分子量: 447.35
• PSA: 56.40000
• LogP: 5.54770
• 储存条件: 2-8℃

GW791343(盐酸盐)英文别名

• N-(3,4-Difluorophenyl)-N-[2-methyl-5-(piperazin-1-ylmethyl)phenyl]glycinamide trihydrochloride
• Acetamide, 2-[(3,4-difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-, hydrochloride (1:3)
• N-(3,4-Difluorophenyl)-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]glycinamide trihydrochloride
• GW791343 (dihydrochloride)