193611-72-2

193611-72-2结构式

中文名	BRL15572 盐酸盐
英文名	BRL 15572 hydrochloride,3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanolhydrochloride
中文别名	四氢罂粟碱盐酸盐
英文别名	1-Piperazineethanol, 4-(3-chlorophenyl)-α-(diphenylmethyl)-, hydrochloride (1:1) 3-[4-(3-Chlorophenyl)-1-piperazinyl]-1,1-diphenyl-2-propanol hydrochloride (1:1) TCMDC-123456 3-[4-(3-Chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride (1:1) 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride BRL-15572 (dihydrochloride)

描述	BRL-15572双盐酸盐是5-HT1D受体拮抗剂,pKi为7.9,与5-HT1A和5-HT2B受体的亲和力同样较强,对5-HT1B受体抑制性较弱。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体研究领域 >> 神经疾病
参考文献	[1]. http://en.wikipedia.org/wiki/BRL-15,572 [2]. Fujii H, Takatori S, Zamami Y, Hashikawa-Hobara N, Miyake N, Tangsucharit P, Mio M, Kawasaki H.Adrenergic stimulation-released 5-HT stored in adrenergic nerves inhibits CGRPergic nerve-mediated vasodilatation in rat mesenteric resistance arteries.Br J Pha [3]. González-Hernández A, Manrique-Maldonado G, Lozano-Cuenca J, Mu?oz-Islas E, Centurión D, Maassen VanDenBrink A, Villalón CM.The 5-HT(1) receptors inhibiting the rat vasodepressor sensory CGRPergic outflow: further involvement of 5-HT(1F), but not 5-HT(1A) [4]. Rocha-González HI, Blaisdell-López E, Granados-Soto V, Navarrete A.Antinociceptive effect of 7-hydroxy-3,4-dihydrocadalin isolated from Heterotheca inuloides: role of peripheral 5-HT? serotonergic receptors.Eur J Pharmacol. 2010 Dec 15;649(1-3):154-60. Ep [5]. González-Hernández A, Mu?oz-Islas E, Lozano-Cuenca J, Ramírez-Rosas MB, Sánchez-López A, Centurión D, Ramírez-San Juan E, Villalón CM.Activation of 5-HT1B receptors inhibits the vasodepressor sensory CGRPergic outflow in pithed rats.Eur J Pharmacol. 2010