1313883-00-9

• 常用中文名：ARQ092盐酸盐
• 常用英文名：Miransertib HCl
• CAS号：1313883-00-9
• 分子式：C₂₇H₂₅ClN₆
• 分子量：468.981
• 发布时间：2018-12-06 13:36:38
• 更新时间：2024-03-03 15:59:06
• Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. ARQ-092 demonstrated high enzymatic potency against AKT1, AKT2, and AKT3, as well as potent cellular inhibition of AKT activation and the phosphorylation of the downstream target PRAS40. ARQ-092 also served as a potent inhibitor of the AKT1-E17K mutant protein and inhibited tumor growth in a human xenograft mouse model of endometrial adenocarcinoma.

名称

• 中文名: ARQ092盐酸盐
• 英文名: 3-{3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl}-2-pyridinamine hydrochloride (1:1)
• 英文别名: 3-{3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl}-2-pyridinamine hydrochloride (1:1); MFCD31536778; 2-Pyridinamine, 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-, hydrochloride (1:1)

物化性质

• 分子式: C₂₇H₂₅ClN₆
• 分子量: 468.981
• 精确质量: 468.182922
• 外观性状: 粉末
• 储存条件: -20℃