1313883-00-9

1313883-00-9结构式

常用中文名：ARQ092盐酸盐
常用英文名：Miransertib HCl
CAS号：1313883-00-9
分子式：C₂₇H₂₅ClN₆
分子量：468.981
发布时间：2018-12-06 13:36:38
更新时间：2025-11-30 07:24:13
Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. ARQ-092 demonstrated high enzymatic potency against AKT1, AKT2, and AKT3, as well as potent cellular inhibition of AKT activation and the phosphorylation of the downstream target PRAS40. ARQ-092 also served as a potent inhibitor of the AKT1-E17K mutant protein and inhibited tumor growth in a human xenograft mouse model of endometrial adenocarcinoma.

中文名	ARQ092盐酸盐
英文名	3-{3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl}-2-pyridinamine hydrochloride (1:1)
英文别名	3-{3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl}-2-pyridinamine hydrochloride (1:1) MFCD31536778 2-Pyridinamine, 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-, hydrochloride (1:1)