木防己苦毒素

一般危化品
更新时间:2024-01-03 12:23:30

木防己苦毒素结构式
木防己苦毒素结构式
常用名 木防己苦毒素 英文名 Picrotoxin
CAS号 124-87-8 分子量 301.29
密度 N/A 沸点 N/A
分子式 C15H18O7.C15H16O6 熔点 203 ℃(lit.)
MSDS 中文版 美版 闪点 N/A
符号 GHS06
GHS06
信号词 Danger

 木防己苦毒素用途


Picrotoxin 是一种非竞争性的 GABAA receptor 拮抗剂。

 木防己苦毒素名称

中文名 苦毒浆果[木防已属]
英文名 Picrotoxin,1:1mixtureofpicrotoxininandpicrotin
中文别名 印防己毒素
英文别名 更多

 木防己苦毒素物理化学性质

熔点 203 ℃(lit.)
分子式 C15H18O7.C15H16O6
分子量 301.29
PSA 190.95000
外观性状 白色到极淡的黄色晶体或粉末
储存条件 -20°C
计算化学

1、 疏水参数计算参考值(XlogP):

2、 氢键供体数量:3

3、 氢键受体数量:13

4、 可旋转化学键数量:2

5、 互变异构体数量:

6、 拓扑分子极性表面积(TPSA):191

7、 重原子数量:43

8、 表面电荷:0

9、 复杂度:1290

10、同位素原子数量:0

11、确定原子立构中心数量:11

12、不确定原子立构中心数量:5

13、确定化学键立构中心数量:0

14、不确定化学键立构中心数量:0

15、共价键单元数量:2

 木防己苦毒素MSDS

 木防己苦毒素毒性和生态

 木防己苦毒素安全信息

符号 GHS06
GHS06
信号词 Danger
危害声明 H300
警示性声明 P264-P301 + P310
个人防护装备 Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) T+;N
风险声明 (欧洲) 28-52/53
安全声明 (欧洲) 28-36/37/39-45-61
危险品运输编码 UN 3462 6.1/PG 2
WGK德国 3
RTECS号 TJ9100000
包装等级 I

 木防己苦毒素文献114

更多文献
Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.

J. Neurosci. 34(35) , 11769-80, (2014)

Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hip...

Parallel ON and OFF cone bipolar inputs establish spatially coextensive receptive field structure of blue-yellow ganglion cells in primate retina.

J. Mol. Endocrinol. 29 , 8372-87, (2009)

In the primate retina the small bistratified, "blue-yellow" color-opponent ganglion cell receives parallel ON-depolarizing and OFF-hyperpolarizing inputs from short (S)-wavelength sensitive and combin...

Modifications of diflunisal and meclofenamate carboxyl groups affect their allosteric effects on GABAA receptor ligand binding.

Neurochem. Res. 39(7) , 1183-91, (2014)

Gamma-aminobutyric acid type A receptors (GABAAR) are allosterically modulated by the nonsteroidal anti-inflammatory drugs diflunisal and fenamates. The carboxyl group of these compounds is charged at...

 木防己苦毒素英文别名

(1R,3R,5S,8S,9R,12S,13R,14R)-1-Hydroxy-13-methyl-14-(prop-1-en-2-yl)-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tetradecane-6,11-dione - (1R,3R,5S,8S,9R,12S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tetradecane-6,11-dione (1:1)
Picrotox
EINECS 204-716-6
PICROTOXIN
3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-, compd. with (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione (1:1)
fishberry
(1R,3R,5S,8S,9R,12S,13R,14R)-1-Hydroxy-14-isopropenyl-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tetradecan-6,11-dion--(1R,3R,5S,8S,9R,12S,13R,14S)-1-hydroxy-14-(2-hydroxy-2-propanyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tetradecan-6,11-dion(1:1)
indianberry
Picrotin - Picrotoxinin
(1R,3R,5S,8S,9R,12S,13R,14R)-1-Hydroxy-13-méthyl-14-(1-propèn-2-yl)-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tétradécane-6,11-dione - (1R,3R,5S,8S,9R,12S,13R,14S)-1-hydroxy-14-(2-hydroxy-2-propanyl)-13-méthyl-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tétradécane-6,11-dione (1:1)
(1R,3R,5S,8S,9R,12S,13R,14R)-1-Hydroxy-14-isopropenyl-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tetradecane-6,11-dione - (1R,3R,5S,8S,9R,12S,13R,14S)-1-hydroxy-14-(2-hydroxy-2-propanyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tetradecane-6,11-dione (1:1)
picrotoxine
MFCD00074824
(1R,3R,5S,8S,9R,12S,13R,14R)-1-Hydroxy-14-isopropenyl-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tetradecane-6,11-dione - (1R,3R,5S,8S,9R,12S,13R,14S)-1-hydroxy-14-(2-hydroxy-2-pro panyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1.0.0]tetradecane-6,11-dione (1:1)
COCCULIN
COCCULINE
Cocculus